Cell Senescence Entries for RUNX1

Cell Types
Foreskin fibroblast
Cell Lines
HS68
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Wolyniec et al. (2009) RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress. Oncogene 28(27)2502-12 (PubMed)

RUNX1 Gene Information

HGNC symbol
RUNX1 
Aliases
AML1; AMLCR1; CBFA2; PEBP2A2 
Common name
RUNX family transcription factor 1 
Entrez Id
861
Description
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

RUNX1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II
GO:71425; hematopoietic stem cell proliferation
GO:30182; neuron differentiation
GO:45595; regulation of cell differentiation
GO:30097; hemopoiesis
GO:45766; positive regulation of angiogenesis
GO:32743; positive regulation of interleukin-2 production
GO:1503; ossification
GO:32967; positive regulation of collagen biosynthetic process
GO:1903055; positive regulation of extracellular matrix organization
GO:43371; negative regulation of CD4-positive, alpha-beta T cell differentiation
GO:2573; myeloid leukocyte differentiation
GO:30099; myeloid cell differentiation
GO:30854; positive regulation of granulocyte differentiation
GO:60043; regulation of cardiac muscle cell proliferation
GO:61026; cardiac muscle tissue regeneration
GO:2062; chondrocyte differentiation
GO:48935; peripheral nervous system neuron development
GO:43378; positive regulation of CD8-positive, alpha-beta T cell differentiation
GO:10755; regulation of plasminogen activation
GO:1905203; regulation of connective tissue replacement
GO:51094; positive regulation of developmental process
Cellular component: GO:5634; nucleus
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:785; chromatin
GO:16513; core-binding factor complex
Function: GO:5524; ATP binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5509; calcium ion binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:140297; DNA-binding transcription factor binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1222; transcription corepressor binding
GO:1223; transcription coactivator binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:46982; protein heterodimerization activity
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Homologs of RUNX1 in Model Organisms

Mus musculus
Runx1
Rattus norvegicus
Runx1

External links

OMIM
151385
Ensembl
ENSG00000159216
Entrez Gene
861
UniGene
612648
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RUNX1
GeneCards
RUNX1