Cell Senescence Entries for RUVBL2

Cell Types
Kidney cancer
Cell Lines
A498, KRC/Y
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Ren et al. (2014) Overexpression of reptin in renal cell carcinoma contributes to tumor malignancies and its inhibition triggers senescence of cancer cells. Urol Oncol 31(7)1358-66 (PubMed)

RUVBL2 Gene Information

HGNC symbol
RUVBL2 
Aliases
ECP51; INO80J; Reptin52; RVB2; TIH2; TIP48; TIP49b 
Common name
RuvB like AAA ATPase 2 
Entrez Id
10856
Description
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008].

RUVBL2 Ontologies

Gene Ontology
Process: GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6310; DNA recombination
GO:32508; DNA duplex unwinding
GO:6325; chromatin organization
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45892; negative regulation of transcription, DNA-templated
GO:40008; regulation of growth
GO:6338; chromatin remodeling
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:16573; histone acetylation
GO:43968; histone H2A acetylation
GO:43967; histone H4 acetylation
GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:34644; cellular response to UV
GO:6457; protein folding
GO:42981; regulation of apoptotic process
GO:6275; regulation of DNA replication
GO:42766; nucleosome mobilization
GO:1904874; positive regulation of telomerase RNA localization to Cajal body
GO:71392; cellular response to estradiol stimulus
GO:71169; establishment of protein localization to chromatin
GO:51726; regulation of cell cycle
GO:1905168; positive regulation of double-strand break repair via homologous recombination
GO:33044; regulation of chromosome organization
GO:60382; regulation of DNA strand elongation
GO:45739; positive regulation of DNA repair
GO:50821; protein stabilization
GO:2000779; regulation of double-strand break repair
GO:492; box C/D snoRNP assembly
GO:35066; positive regulation of histone acetylation
GO:723; telomere maintenance
GO:6282; regulation of DNA repair
GO:45995; regulation of embryonic development
GO:1904507; positive regulation of telomere maintenance in response to DNA damage
GO:43486; histone exchange
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:31011; Ino80 complex
GO:35267; NuA4 histone acetyltransferase complex
GO:120293; dynein axonemal particle
GO:97255; R2TP complex
GO:5737; cytoplasm
GO:16020; membrane
GO:5813; centrosome
GO:812; Swr1 complex
GO:16363; nuclear matrix
GO:70062; extracellular exosome
GO:1990062; RPAP3/R2TP/prefoldin-like complex
GO:71339; MLL1 complex
GO:786; nucleosome
GO:791; euchromatin
GO:101031; chaperone complex
GO:1990904; ribonucleoprotein complex
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16787; hydrolase activity
GO:8094; ATPase, acting on DNA
GO:4386; helicase activity
GO:16887; ATP hydrolysis activity
GO:3678; DNA helicase activity
GO:42802; identical protein binding
GO:31490; chromatin DNA binding
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:8013; beta-catenin binding
GO:51082; unfolded protein binding
GO:3714; transcription corepressor activity
GO:979; RNA polymerase II core promoter sequence-specific DNA binding
GO:17025; TBP-class protein binding
GO:1094; TFIID-class transcription factor complex binding
GO:42803; protein homodimerization activity
GO:43531; ADP binding
GO:51117; ATPase binding
GO:140585; promoter-enhancer loop anchoring activity
Hide GO terms

Homologs of RUVBL2 in Model Organisms

Caenorhabditis elegans
ruvb-2
Danio rerio
ruvbl2
Drosophila melanogaster
rept
Mus musculus
Ruvbl2
Rattus norvegicus
Ruvbl2
Saccharomyces cerevisiae
RVB2
Schizosaccharomyces pombe
rvb2

External links

OMIM
604788
Ensembl
ENSG00000183207
Entrez Gene
10856
UniGene
515846
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RUVBL2
GeneCards
RUVBL2