Cell Senescence Entries for RUVBL2
- Cell Types
- Kidney cancer
- Cell Lines
- A498, KRC/Y
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Ren et al. (2014) Overexpression of reptin in renal cell carcinoma contributes to tumor malignancies and its inhibition triggers senescence of cancer cells. Urol Oncol 31(7)1358-66 (PubMed)
RUVBL2 Gene Information
- HGNC symbol
- RUVBL2
- Aliases
- ECP51; INO80J; Reptin52; RVB2; TIH2; TIP48; TIP49b
- Common name
- RuvB like AAA ATPase 2
- Entrez Id
- 10856
- Description
- This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008].
RUVBL2 Ontologies
- Gene Ontology
-
Process: GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6310; DNA recombination
GO:32508; DNA duplex unwinding
GO:6325; chromatin organization
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45892; negative regulation of transcription, DNA-templated
GO:40008; regulation of growth
GO:6338; chromatin remodeling
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:16573; histone acetylation
GO:43968; histone H2A acetylation
GO:43967; histone H4 acetylation
GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:34644; cellular response to UV
GO:6457; protein folding
GO:42981; regulation of apoptotic process
GO:6275; regulation of DNA replication
GO:42766; nucleosome mobilization
GO:1904874; positive regulation of telomerase RNA localization to Cajal body
GO:71392; cellular response to estradiol stimulus
GO:71169; establishment of protein localization to chromatin
GO:51726; regulation of cell cycle
GO:1905168; positive regulation of double-strand break repair via homologous recombination
GO:33044; regulation of chromosome organization
GO:60382; regulation of DNA strand elongation
GO:45739; positive regulation of DNA repair
GO:50821; protein stabilization
GO:2000779; regulation of double-strand break repair
GO:492; box C/D snoRNP assembly
GO:35066; positive regulation of histone acetylation
GO:723; telomere maintenance
GO:6282; regulation of DNA repair
GO:45995; regulation of embryonic development
GO:1904507; positive regulation of telomere maintenance in response to DNA damage
GO:43486; histone exchange
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:31011; Ino80 complex
GO:35267; NuA4 histone acetyltransferase complex
GO:120293; dynein axonemal particle
GO:97255; R2TP complex
GO:5737; cytoplasm
GO:16020; membrane
GO:5813; centrosome
GO:812; Swr1 complex
GO:16363; nuclear matrix
GO:70062; extracellular exosome
GO:1990062; RPAP3/R2TP/prefoldin-like complex
GO:71339; MLL1 complex
GO:786; nucleosome
GO:791; euchromatin
GO:101031; chaperone complex
GO:1990904; ribonucleoprotein complex
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16787; hydrolase activity
GO:8094; ATPase, acting on DNA
GO:4386; helicase activity
GO:16887; ATP hydrolysis activity
GO:3678; DNA helicase activity
GO:42802; identical protein binding
GO:31490; chromatin DNA binding
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:8013; beta-catenin binding
GO:51082; unfolded protein binding
GO:3714; transcription corepressor activity
GO:979; RNA polymerase II core promoter sequence-specific DNA binding
GO:17025; TBP-class protein binding
GO:1094; TFIID-class transcription factor complex binding
GO:42803; protein homodimerization activity
GO:43531; ADP binding
GO:51117; ATPase binding
GO:140585; promoter-enhancer loop anchoring activity
Homologs of RUVBL2 in Model Organisms
- Caenorhabditis elegans
- ruvb-2
- Danio rerio
- ruvbl2
- Drosophila melanogaster
- rept
- Mus musculus
- Ruvbl2
- Rattus norvegicus
- Ruvbl2
- Saccharomyces cerevisiae
- RVB2
- Schizosaccharomyces pombe
- rvb2
External links
- OMIM
- 604788
- Ensembl
- ENSG00000183207
- Entrez Gene
- 10856
- UniGene
- 515846
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RUVBL2
- GeneCards
- RUVBL2