Cell Senescence Entries for S100A6

Cell Types
Umbilical vein endothelial
Cell Lines
HUVEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Bao et al. (2013) The S100A6 calcium-binding protein regulates endothelial cell-cycle progression and senescence. FEBS J 279(24)4576-88 (PubMed)

S100A6 Gene Information

HGNC symbol
S100A6 
Aliases
2A9; CABP; CACY; PRA 
Common name
S100 calcium binding protein A6 
Entrez Id
6277
Description
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008].

S100A6 Ontologies

Gene Ontology
Process: GO:34220; ion transmembrane transport
GO:7165; signal transduction
GO:7409; axonogenesis
GO:48146; positive regulation of fibroblast proliferation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5635; nuclear envelope
GO:48471; perinuclear region of cytoplasm
GO:1726; ruffle
GO:31234; extrinsic component of cytoplasmic side of plasma membrane
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:5576; extracellular region
Function: GO:46872; metal ion binding
GO:5509; calcium ion binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:48306; calcium-dependent protein binding
GO:44548; S100 protein binding
GO:5523; tropomyosin binding
GO:8270; zinc ion binding
GO:15075; ion transmembrane transporter activity
Hide GO terms

Homologs of S100A6 in Model Organisms

Mus musculus
S100a6
Rattus norvegicus
S100a6

In other databases

GenAge microarray genes
  • This gene is present as S100A6

External links

OMIM
114110
Ensembl
ENSG00000197956
Entrez Gene
6277
UniGene
275243
1000 Genomes
1000 Genomes
HPRD
GenAtlas
S100A6
GeneCards
S100A6