Cell Senescence Entries for SAMHD1

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Kretschmer et al. (2015) SAMHD1 prevents autoimmunity by maintaining genome stability. Ann Rheum Dis 74(3)e17 (PubMed)

SAMHD1 Gene Information

HGNC symbol
SAMHD1 
Aliases
AGS5; HDDC1; Mg11; MOP-5; SBBI88 
Common name
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 
Entrez Id
25939
Description
This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010].

SAMHD1 Ontologies

Gene Ontology
Process: GO:90501; RNA phosphodiester bond hydrolysis
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:8152; metabolic process
GO:6260; DNA replication
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:6955; immune response
GO:45088; regulation of innate immune response
GO:724; double-strand break repair via homologous recombination
GO:51289; protein homotetramerization
GO:16446; somatic hypermutation of immunoglobulin genes
GO:60339; negative regulation of type I interferon-mediated signaling pathway
GO:110025; DNA strand resection involved in replication fork processing
GO:6203; dGTP catabolic process
GO:9264; deoxyribonucleotide catabolic process
GO:46061; dATP catabolic process
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5694; chromosome
GO:35861; site of double-strand break
GO:97197; tetraspanin-enriched microdomain
Function: GO:3723; RNA binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:16787; hydrolase activity
GO:8270; zinc ion binding
GO:5525; GTP binding
GO:3824; catalytic activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:3676; nucleic acid binding
GO:3697; single-stranded DNA binding
GO:4540; ribonuclease activity
GO:8832; dGTPase activity
GO:16793; triphosphoric monoester hydrolase activity
GO:32567; dGTP binding
GO:106375; deoxynucleoside triphosphate hydrolase activity
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Homologs of SAMHD1 in Model Organisms

Caenorhabditis elegans
ZK177.8
Danio rerio
samhd1
Mus musculus
Samhd1
Rattus norvegicus
Samhd1

External links

OMIM
606754
Ensembl
ENSG00000101347
Entrez Gene
25939
UniGene
580681
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SAMHD1
GeneCards
SAMHD1