Cell Senescence Entries for SELENBP1

Cell Types
Esophageal cancer
Cell Lines
FLO-1
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Silvers et al. (2010) Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity. Clin Cancer Res 16(7)2009-21 (PubMed)

SELENBP1 Gene Information

HGNC symbol
SELENBP1 
Aliases
hSBP; hSP56; LPSB 
Common name
selenium binding protein 1 
Entrez Id
8991
Description
This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].

SELENBP1 Ontologies

Gene Ontology
Process: GO:15031; protein transport
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5730; nucleolus
GO:1650; fibrillar center
GO:5829; cytosol
GO:5615; extracellular space
GO:70062; extracellular exosome
Function: GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:8430; selenium binding
GO:18549; methanethiol oxidase activity
Hide GO terms

Homologs of SELENBP1 in Model Organisms

Caenorhabditis elegans
CELE_Y37A1B.5
Danio rerio
selenbp1
Drosophila melanogaster
CG7966
Mus musculus
Selenbp2
Rattus norvegicus
Selenbp1

In other databases

CellAge gene expression

External links

OMIM
604188
Ensembl
ENSG00000143416
Entrez Gene
8991
UniGene
632460
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SELENBP1
GeneCards
SELENBP1