Cell Senescence Entries for SENP1
- Cell Types
- Foreskin fibroblast
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Yates et al. (2008) Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging Cell 7(5)609-21 (PubMed)
SENP1 Gene Information
- HGNC symbol
- SENP1
- Aliases
- Common name
- SUMO specific peptidase 1
- Entrez Id
- 29843
- Description
- This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012].
SENP1 Ontologies
- Gene Ontology
-
Process: GO:6508; proteolysis
GO:16926; protein desumoylation
GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:97190; apoptotic signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:31965; nuclear membrane
GO:5925; focal adhesion
Hide GO termsFunction: GO:8233; peptidase activity
GO:8234; cysteine-type peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:4175; endopeptidase activity
GO:70140; SUMO-specific isopeptidase activity
GO:70139; SUMO-specific endopeptidase activity
Homologs of SENP1 in Model Organisms
- Danio rerio
- si:dkey-21c19.3
- Mus musculus
- Senp1
- Rattus norvegicus
- Senp1
External links
- OMIM
- 612157
- Ensembl
- ENSG00000079387
- Entrez Gene
- 29843
- UniGene
- 371957
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SENP1
- GeneCards
- SENP1