Cell Senescence Entries for SERPINE1

Cell Types
Foreskin fibroblast
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Kortlever et al. (2006) Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol 8(8)877-84 (PubMed)

SERPINE1 Gene Information

HGNC symbol
SERPINE1 
Aliases
PAI; PAI1; PLANH1 
Common name
serpin family E member 1 
Entrez Id
5054
Description
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. [provided by RefSeq, Aug 2020].

SERPINE1 Ontologies

Gene Ontology
Process: GO:10951; negative regulation of endopeptidase activity
GO:1525; angiogenesis
GO:10466; negative regulation of peptidase activity
GO:32757; positive regulation of interleukin-8 production
GO:50729; positive regulation of inflammatory response
GO:50829; defense response to Gram-negative bacterium
GO:71222; cellular response to lipopolysaccharide
GO:45766; positive regulation of angiogenesis
GO:48260; positive regulation of receptor-mediated endocytosis
GO:61045; negative regulation of wound healing
GO:30336; negative regulation of cell migration
GO:1902042; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352; negative regulation of endothelial cell apoptotic process
GO:33629; negative regulation of cell adhesion mediated by integrin
GO:14912; negative regulation of smooth muscle cell migration
GO:30194; positive regulation of blood coagulation
GO:51918; negative regulation of fibrinolysis
GO:10469; regulation of signaling receptor activity
GO:42730; fibrinolysis
GO:61044; negative regulation of vascular wound healing
GO:30195; negative regulation of blood coagulation
GO:10757; negative regulation of plasminogen activation
GO:35491; positive regulation of leukotriene production involved in inflammatory response
GO:90026; positive regulation of monocyte chemotaxis
GO:90399; replicative senescence
GO:97187; dentinogenesis
GO:1901331; positive regulation of odontoblast differentiation
GO:2000098; negative regulation of smooth muscle cell-matrix adhesion
Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:5886; plasma membrane
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:31093; platelet alpha granule lumen
GO:97180; serine protease inhibitor complex
GO:1904090; peptidase inhibitor complex
Function: GO:4867; serine-type endopeptidase inhibitor activity
GO:5515; protein binding
GO:30414; peptidase inhibitor activity
GO:2020; protease binding
GO:5102; signaling receptor binding
Hide GO terms

Homologs of SERPINE1 in Model Organisms

Caenorhabditis elegans
srp-3
Danio rerio
serpine1
Mus musculus
Serpine1
Rattus norvegicus
Serpine1

In other databases

GenAge human genes
LongevityMap

External links

OMIM
173360
Ensembl
ENSG00000106366
Entrez Gene
5054
UniGene
713079
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SERPINE1
GeneCards
SERPINE1