Cell Senescence Entries for SFRP1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Elzi et al. (2013) Wnt antagonist SFRP1 functions as a secreted mediator of senescence. Mol Cell Biol 32(21)4388-99 (PubMed)

SFRP1 Gene Information

HGNC symbol
SFRP1 
Aliases
FRP; FRP-1; SARP2 
Common name
secreted frizzled related protein 1 
Entrez Id
6422
Description
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009].

SFRP1 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:16055; Wnt signaling pathway
GO:6508; proteolysis
GO:45893; positive regulation of transcription, DNA-templated
GO:43065; positive regulation of apoptotic process
GO:10629; negative regulation of gene expression
GO:30177; positive regulation of Wnt signaling pathway
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:8284; positive regulation of cell population proliferation
GO:71363; cellular response to growth factor stimulus
GO:8285; negative regulation of cell population proliferation
GO:14070; response to organic cyclic compound
GO:45880; positive regulation of smoothened signaling pathway
GO:30308; negative regulation of cell growth
GO:9267; cellular response to starvation
GO:30178; negative regulation of Wnt signaling pathway
GO:71347; cellular response to interleukin-1
GO:71356; cellular response to tumor necrosis factor
GO:60070; canonical Wnt signaling pathway
GO:43547; positive regulation of GTPase activity
GO:71560; cellular response to transforming growth factor beta stimulus
GO:30307; positive regulation of cell growth
GO:1954; positive regulation of cell-matrix adhesion
GO:44344; cellular response to fibroblast growth factor stimulus
GO:51496; positive regulation of stress fiber assembly
GO:51894; positive regulation of focal adhesion assembly
GO:50680; negative regulation of epithelial cell proliferation
GO:71456; cellular response to hypoxia
GO:71391; cellular response to estrogen stimulus
GO:10719; negative regulation of epithelial to mesenchymal transition
GO:30336; negative regulation of cell migration
GO:50679; positive regulation of epithelial cell proliferation
GO:2000271; positive regulation of fibroblast apoptotic process
GO:1649; osteoblast differentiation
GO:45765; regulation of angiogenesis
GO:45600; positive regulation of fat cell differentiation
GO:71392; cellular response to estradiol stimulus
GO:30279; negative regulation of ossification
GO:60766; negative regulation of androgen receptor signaling pathway
GO:71504; cellular response to heparin
GO:60218; hematopoietic stem cell differentiation
GO:2244; hematopoietic progenitor cell differentiation
GO:45578; negative regulation of B cell differentiation
GO:1902043; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:48147; negative regulation of fibroblast proliferation
GO:46676; negative regulation of insulin secretion
GO:33689; negative regulation of osteoblast proliferation
GO:10564; regulation of cell cycle process
GO:71773; cellular response to BMP stimulus
GO:50732; negative regulation of peptidyl-tyrosine phosphorylation
GO:2000270; negative regulation of fibroblast apoptotic process
GO:2000052; positive regulation of non-canonical Wnt signaling pathway
GO:1657; ureteric bud development
GO:1756; somitogenesis
GO:1843; neural tube closure
GO:8584; male gonad development
GO:8585; female gonad development
GO:9410; response to xenobiotic stimulus
GO:9950; dorsal/ventral axis specification
GO:9952; anterior/posterior pattern specification
GO:10975; regulation of neuron projection development
GO:14034; neural crest cell fate commitment
GO:21915; neural tube development
GO:30097; hemopoiesis
GO:30514; negative regulation of BMP signaling pathway
GO:35019; somatic stem cell population maintenance
GO:43508; negative regulation of JUN kinase activity
GO:44345; stromal-epithelial cell signaling involved in prostate gland development
GO:45668; negative regulation of osteoblast differentiation
GO:45671; negative regulation of osteoclast differentiation
GO:46546; development of primary male sexual characteristics
GO:46851; negative regulation of bone remodeling
GO:48546; digestive tract morphogenesis
GO:60071; Wnt signaling pathway, planar cell polarity pathway
GO:60346; bone trabecula formation
GO:60527; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:60687; regulation of branching involved in prostate gland morphogenesis
GO:71305; cellular response to vitamin D
GO:71380; cellular response to prostaglandin E stimulus
GO:71481; cellular response to X-ray
GO:71542; dopaminergic neuron differentiation
GO:90175; regulation of establishment of planar polarity
GO:90179; planar cell polarity pathway involved in neural tube closure
GO:90244; Wnt signaling pathway involved in somitogenesis
GO:90246; convergent extension involved in somitogenesis
GO:1904956; regulation of midbrain dopaminergic neuron differentiation
GO:2000041; negative regulation of planar cell polarity pathway involved in axis elongation
GO:2000054; negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:2000080; negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2001238; positive regulation of extrinsic apoptotic signaling pathway
GO:48856; anatomical structure development
Cellular component: GO:5615; extracellular space
GO:5886; plasma membrane
GO:5576; extracellular region
GO:5829; cytosol
GO:9986; cell surface
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
Function: GO:5515; protein binding
GO:8201; heparin binding
GO:4197; cysteine-type endopeptidase activity
GO:17147; Wnt-protein binding
GO:5109; frizzled binding
GO:42802; identical protein binding
Hide GO terms

Homologs of SFRP1 in Model Organisms

Mus musculus
Sfrp1

In other databases

CellAge gene expression
  • This gene is present as SFRP1

External links

OMIM
604156
Ensembl
ENSG00000104332
Entrez Gene
6422
UniGene
213424
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SFRP1
GeneCards
SFRP1