Cell Senescence Entries for SIAH1

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Fujita et al. (2011) Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence. Nat Cell Biol 12(12)1205-12 (PubMed)

SIAH1 Gene Information

HGNC symbol
SIAH1 
Aliases
hSIAH1 
Common name
siah E3 ubiquitin protein ligase 1 
Entrez Id
6477
Description
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

SIAH1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:16567; protein ubiquitination
GO:6915; apoptotic process
GO:30154; cell differentiation
GO:6511; ubiquitin-dependent protein catabolic process
GO:43065; positive regulation of apoptotic process
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:7283; spermatogenesis
GO:7399; nervous system development
GO:9653; anatomical structure morphogenesis
GO:2001244; positive regulation of intrinsic apoptotic signaling pathway
GO:51402; neuron apoptotic process
GO:30163; protein catabolic process
GO:7411; axon guidance
GO:60070; canonical Wnt signaling pathway
GO:1990000; amyloid fibril formation
GO:7275; multicellular organism development
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:30877; beta-catenin destruction complex
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:5515; protein binding
GO:4842; ubiquitin-protein transferase activity
GO:61630; ubiquitin protein ligase activity
GO:42802; identical protein binding
GO:8022; protein C-terminus binding
GO:31624; ubiquitin conjugating enzyme binding
Hide GO terms

Homologs of SIAH1 in Model Organisms

Danio rerio
siah1
Mus musculus
Siah1a
Rattus norvegicus
Siah1

External links

OMIM
602212
Ensembl
ENSG00000196470
Entrez Gene
6477
UniGene
706828
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SIAH1
GeneCards
SIAH1