Cell Senescence Entries for SIRT6

Cell Types
Chondrocyte
Cell Lines
NHAC-kn
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Nagai et al. (2016) Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes. Osteoarthritis Cartilage 23(8)1412-20 (PubMed)

SIRT6 Gene Information

HGNC symbol
SIRT6 
Aliases
 
Common name
sirtuin 6 
Entrez Id
51548
Description
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].

SIRT6 Ontologies

Gene Ontology
Process: GO:61647; histone H3-K9 modification
GO:1990619; histone H3-K9 deacetylation
GO:6471; protein ADP-ribosylation
GO:122; negative regulation of transcription by RNA polymerase II
GO:10569; regulation of double-strand break repair via homologous recombination
GO:120162; positive regulation of cold-induced thermogenesis
GO:1905564; positive regulation of vascular endothelial cell proliferation
GO:32206; positive regulation of telomere maintenance
GO:70932; histone H3 deacetylation
GO:31509; subtelomeric heterochromatin assembly
GO:45814; negative regulation of gene expression, epigenetic
GO:6476; protein deacetylation
GO:1901485; positive regulation of transcription factor catabolic process
GO:1902732; positive regulation of chondrocyte proliferation
GO:1905555; positive regulation of blood vessel branching
GO:6284; base-excision repair
GO:8285; negative regulation of cell population proliferation
GO:31648; protein destabilization
GO:42593; glucose homeostasis
GO:45820; negative regulation of glycolytic process
GO:45892; negative regulation of transcription, DNA-templated
GO:46325; negative regulation of glucose import
GO:48146; positive regulation of fibroblast proliferation
GO:2000648; positive regulation of stem cell proliferation
Cellular component: GO:5634; nucleus
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:99115; chromosome, subtelomeric region
Function: GO:16740; transferase activity
GO:46872; metal ion binding
GO:8270; zinc ion binding
GO:70403; NAD+ binding
GO:5515; protein binding
GO:3714; transcription corepressor activity
GO:19213; deacetylase activity
GO:3956; NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:4407; histone deacetylase activity
GO:3950; NAD+ ADP-ribosyltransferase activity
GO:17136; NAD-dependent histone deacetylase activity
GO:34979; NAD-dependent protein deacetylase activity
GO:46969; NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:3682; chromatin binding
Hide GO terms

Homologs of SIRT6 in Model Organisms

Caenorhabditis elegans
sir-2.4
Danio rerio
sirt6
Drosophila melanogaster
Sirt6
Mus musculus
Sirt6
Rattus norvegicus
Sirt6

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Sirt6
  • A homolog of this gene for Drosophila melanogaster is present as Sirt6
GenAge human genes
  • This gene is present as SIRT6
LongevityMap
  • This gene is present as SIRT6

External links

OMIM
606211
Ensembl
ENSG00000077463
Entrez Gene
51548
UniGene
423756
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SIRT6
GeneCards
SIRT6