Cell Senescence Entries for SIX1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Adrados et al. (2017) The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes. Oncogene 35(27)3485-94 (PubMed)

SIX1 Gene Information

HGNC symbol
SIX1 
Aliases
DFNA23 
Common name
SIX homeobox 1 
Entrez Id
6495
Description
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008].

SIX1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45892; negative regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:1822; kidney development
GO:6357; regulation of transcription by RNA polymerase II
GO:48699; generation of neurons
GO:7389; pattern specification process
GO:43524; negative regulation of neuron apoptotic process
GO:30855; epithelial cell differentiation
GO:30878; thyroid gland development
GO:48538; thymus development
GO:34504; protein localization to nucleus
GO:51451; myoblast migration
GO:90336; positive regulation of brown fat cell differentiation
GO:42472; inner ear morphogenesis
GO:48701; embryonic cranial skeleton morphogenesis
GO:1657; ureteric bud development
GO:7519; skeletal muscle tissue development
GO:48839; inner ear development
GO:90190; positive regulation of branching involved in ureteric bud morphogenesis
GO:1658; branching involved in ureteric bud morphogenesis
GO:48704; embryonic skeletal system morphogenesis
GO:72075; metanephric mesenchyme development
GO:72107; positive regulation of ureteric bud formation
GO:45664; regulation of neuron differentiation
GO:122; negative regulation of transcription by RNA polymerase II
GO:1759; organ induction
GO:3151; outflow tract morphogenesis
GO:7219; Notch signaling pathway
GO:7605; sensory perception of sound
GO:8582; regulation of synaptic assembly at neuromuscular junction
GO:10467; gene expression
GO:10468; regulation of gene expression
GO:14033; neural crest cell differentiation
GO:14842; regulation of skeletal muscle satellite cell proliferation
GO:14857; regulation of skeletal muscle cell proliferation
GO:21610; facial nerve morphogenesis
GO:22008; neurogenesis
GO:30910; olfactory placode formation
GO:32880; regulation of protein localization
GO:35909; aorta morphogenesis
GO:42474; middle ear morphogenesis
GO:43066; negative regulation of apoptotic process
GO:43586; tongue development
GO:48665; neuron fate specification
GO:48705; skeletal system morphogenesis
GO:48741; skeletal muscle fiber development
GO:48856; anatomical structure development
GO:50678; regulation of epithelial cell proliferation
GO:60037; pharyngeal system development
GO:61055; myotome development
GO:61197; fungiform papilla morphogenesis
GO:61551; trigeminal ganglion development
GO:71599; otic vesicle development
GO:72095; regulation of branch elongation involved in ureteric bud branching
GO:72172; mesonephric tubule formation
GO:72193; ureter smooth muscle cell differentiation
GO:72513; positive regulation of secondary heart field cardioblast proliferation
GO:86100; endothelin receptor signaling pathway
GO:90103; cochlea morphogenesis
GO:1905243; cellular response to 3,3',5-triiodo-L-thyronine
GO:2000729; positive regulation of mesenchymal cell proliferation involved in ureter development
GO:2001014; regulation of skeletal muscle cell differentiation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:785; chromatin
GO:5667; transcription regulator complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:976; transcription cis-regulatory region binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:1223; transcription coactivator binding
GO:3682; chromatin binding
Hide GO terms

Homologs of SIX1 in Model Organisms

Danio rerio
six1b
Mus musculus
Six1
Rattus norvegicus
Six1

External links

OMIM
601205
Ensembl
ENSG00000126778
Entrez Gene
6495
UniGene
633506
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SIX1
GeneCards
SIX1