Cell Senescence Entries for SIX6
- Cell Types
- Fetal retinal progenitor cells
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Mutation
- Type of senescence
- Unclear
- Senescence Effect
- Unclear
- Primary Reference
- Skowronska-Krawczyk et al. (2015) P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma. Mol Cell 59(6)931-40 (PubMed)
SIX6 Gene Information
- HGNC symbol
- SIX6
- Aliases
- OPTX2; Six9
- Common name
- SIX homeobox 6
- Entrez Id
- 4990
- Description
- The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008].
SIX6 Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:1654; eye development
GO:7601; visual perception
GO:9887; animal organ morphogenesis
GO:7275; multicellular organism development
Cellular component: GO:5634; nucleus
GO:785; chromatin
GO:5667; transcription regulator complex
Hide GO termsFunction: GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
Homologs of SIX6 in Model Organisms
External links
- OMIM
- 606326
- Ensembl
- ENSG00000184302
- Entrez Gene
- 4990
- UniGene
- 194756
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SIX6
- GeneCards
- SIX6