Cell Senescence Entries for SLC25A5

Cell Types
Breast cancer, Osteosarcoma
Cell Lines
MCF-7, U2OS
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Kretova et al. (2015) TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence. Cell Signal 26(12)2903-11 (PubMed)

SLC25A5 Gene Information

HGNC symbol
SLC25A5 
Aliases
2F1; ANT2; T2; T3 
Common name
solute carrier family 25 member 5 
Entrez Id
292
Description
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013].

SLC25A5 Ontologies

Gene Ontology
Process: GO:55085; transmembrane transport
GO:1902600; proton transmembrane transport
GO:7059; chromosome segregation
GO:8284; positive regulation of cell population proliferation
GO:140021; mitochondrial ADP transmembrane transport
GO:1990544; mitochondrial ATP transmembrane transport
GO:30218; erythrocyte differentiation
GO:1901029; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1990845; adaptive thermogenesis
GO:30183; B cell differentiation
GO:15853; adenine transport
GO:46902; regulation of mitochondrial membrane permeability
GO:51503; adenine nucleotide transport
GO:1901526; positive regulation of mitophagy
GO:1990830; cellular response to leukemia inhibitory factor
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:16021; integral component of membrane
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5887; integral component of plasma membrane
GO:42645; mitochondrial nucleoid
GO:71817; MMXD complex
GO:5757; mitochondrial permeability transition pore complex
Function: GO:3723; RNA binding
GO:5515; protein binding
GO:15297; antiporter activity
GO:5471; ATP:ADP antiporter activity
GO:31625; ubiquitin protein ligase binding
GO:295; adenine nucleotide transmembrane transporter activity
GO:15078; proton transmembrane transporter activity
GO:15207; adenine transmembrane transporter activity
GO:17077; oxidative phosphorylation uncoupler activity
Hide GO terms

Homologs of SLC25A5 in Model Organisms

Mus musculus
Slc25a5
Rattus norvegicus
Slc25a5

In other databases

CellAge gene expression

External links

OMIM
300150
Ensembl
ENSG00000005022
Entrez Gene
292
UniGene
632282
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SLC25A5
GeneCards
SLC25A5