The SMAD3 gene and its putative association with human ageing

Cell Types

Mammary epithelial

Cell Lines

Primary cell

Cancer Cell?

No

Method

Knockdown

Type of senescence

Stress-induced

Senescence Effect

Induces

Primary Reference

Bryson et al. (2017) STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. Cell Cycle 16(4)319-334 (PubMed)

HGNC symbol

SMAD3

Aliases

HsT17436; JV15-2; MADH3

Common name

SMAD family member 3

Entrez Id

4088

Description

The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. It also functions as a tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, Nov 2019].

Gene Ontology

Process:

GO:6355; regulation of transcription, DNA-templated
GO:7179; transforming growth factor beta receptor signaling pathway
GO:10628; positive regulation of gene expression
GO:45944; positive regulation of transcription by RNA polymerase II
GO:90101; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:90287; regulation of cellular response to growth factor stimulus
GO:122; negative regulation of transcription by RNA polymerase II
GO:165; MAPK cascade
GO:1501; skeletal system development
GO:1649; osteoblast differentiation
GO:1657; ureteric bud development
GO:1701; in utero embryonic development
GO:1707; mesoderm formation
GO:1756; somitogenesis
GO:1889; liver development
GO:1947; heart looping
GO:2076; osteoblast development
GO:2520; immune system development
GO:7183; SMAD protein complex assembly
GO:7254; JNK cascade
GO:7369; gastrulation
GO:7492; endoderm development
GO:8285; negative regulation of cell population proliferation
GO:9880; embryonic pattern specification
GO:10694; positive regulation of alkaline phosphatase activity
GO:16202; regulation of striated muscle tissue development
GO:17015; regulation of transforming growth factor beta receptor signaling pathway
GO:23019; signal transduction involved in regulation of gene expression
GO:30325; adrenal gland development
GO:30335; positive regulation of cell migration
GO:30501; positive regulation of bone mineralization
GO:30878; thyroid gland development
GO:32332; positive regulation of chondrocyte differentiation
GO:32731; positive regulation of interleukin-1 beta production
GO:32916; positive regulation of transforming growth factor beta3 production
GO:33689; negative regulation of osteoblast proliferation
GO:42110; T cell activation
GO:42177; negative regulation of protein catabolic process
GO:43066; negative regulation of apoptotic process
GO:45429; positive regulation of nitric oxide biosynthetic process
GO:45668; negative regulation of osteoblast differentiation
GO:45893; positive regulation of transcription, DNA-templated
GO:48340; paraxial mesoderm morphogenesis
GO:48589; developmental growth
GO:48617; embryonic foregut morphogenesis
GO:48701; embryonic cranial skeleton morphogenesis
GO:50678; regulation of epithelial cell proliferation
GO:50728; negative regulation of inflammatory response
GO:50776; regulation of immune response
GO:50821; protein stabilization
GO:50927; positive regulation of positive chemotaxis
GO:51098; regulation of binding
GO:51496; positive regulation of stress fiber assembly
GO:51894; positive regulation of focal adhesion assembly
GO:60039; pericardium development
GO:60290; transdifferentiation
GO:60395; SMAD protein signal transduction
GO:61045; negative regulation of wound healing
GO:61767; negative regulation of lung blood pressure
GO:70306; lens fiber cell differentiation
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:97296; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:98586; cellular response to virus
GO:1903243; negative regulation of cardiac muscle hypertrophy in response to stress
GO:30154; cell differentiation
GO:9653; anatomical structure morphogenesis
GO:30509; BMP signaling pathway
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:45599; negative regulation of fat cell differentiation
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:97191; extrinsic apoptotic signaling pathway
GO:42060; wound healing
GO:30308; negative regulation of cell growth
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:6955; immune response
GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:42307; positive regulation of protein import into nucleus
GO:32924; activin receptor signaling pathway
GO:71560; cellular response to transforming growth factor beta stimulus
GO:1666; response to hypoxia
GO:45216; cell-cell junction organization
GO:51481; negative regulation of cytosolic calcium ion concentration
GO:32909; regulation of transforming growth factor beta2 production
GO:6357; regulation of transcription by RNA polymerase II
GO:31053; primary miRNA processing
GO:38092; nodal signaling pathway
GO:1901203; positive regulation of extracellular matrix assembly
GO:1902893; regulation of pri-miRNA transcription by RNA polymerase II

Cellular component:

GO:5634; nucleus
GO:5667; transcription regulator complex
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5637; nuclear inner membrane
GO:5886; plasma membrane
GO:32991; protein-containing complex
GO:785; chromatin
GO:43235; receptor complex
GO:71144; heteromeric SMAD protein complex
GO:71141; SMAD protein complex

Function:

GO:5515; protein binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:8270; zinc ion binding
GO:3700; DNA-binding transcription factor activity
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:3682; chromatin binding
GO:3690; double-stranded DNA binding
GO:5518; collagen binding
GO:8013; beta-catenin binding
GO:19899; enzyme binding
GO:31490; chromatin DNA binding
GO:42802; identical protein binding
GO:43565; sequence-specific DNA binding
GO:46332; SMAD binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:1990841; promoter-specific chromatin binding
GO:43130; ubiquitin binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:19901; protein kinase binding
GO:19902; phosphatase binding
GO:42803; protein homodimerization activity
GO:43425; bHLH transcription factor binding
GO:70412; R-SMAD binding
GO:976; transcription cis-regulatory region binding
GO:70410; co-SMAD binding
GO:16922; nuclear receptor binding
GO:31625; ubiquitin protein ligase binding
GO:70411; I-SMAD binding
GO:140297; DNA-binding transcription factor binding
GO:1223; transcription coactivator binding
GO:1217; DNA-binding transcription repressor activity
GO:32810; sterol response element binding
GO:5160; transforming growth factor beta receptor binding
GO:17151; DEAD/H-box RNA helicase binding
GO:31962; mineralocorticoid receptor binding
GO:35259; glucocorticoid receptor binding

Hide GO terms

Danio rerio

Mus musculus

Rattus norvegicus

OMIM

Ensembl

Entrez Gene