Cell Senescence Entries for SMAD6

Cell Types
Lung cancer
Cell Lines
NCI-H460
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Su et al. (2009) BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells. J Biol Chem 284(18)12153-64 (PubMed)

SMAD6 Gene Information

HGNC symbol
SMAD6 
Aliases
HsT17432; MADH6; MADH7 
Common name
SMAD family member 6 
Entrez Id
4091
Description
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014].

SMAD6 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:7179; transforming growth factor beta receptor signaling pathway
GO:30154; cell differentiation
GO:9653; anatomical structure morphogenesis
GO:45444; fat cell differentiation
GO:43066; negative regulation of apoptotic process
GO:30509; BMP signaling pathway
GO:60395; SMAD protein signal transduction
GO:3148; outflow tract septum morphogenesis
GO:8285; negative regulation of cell population proliferation
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:30514; negative regulation of BMP signaling pathway
GO:34616; response to laminar fluid shear stress
GO:60394; negative regulation of pathway-restricted SMAD protein phosphorylation
GO:1657; ureteric bud development
GO:3170; heart valve development
GO:3180; aortic valve morphogenesis
GO:3183; mitral valve morphogenesis
GO:3184; pulmonary valve morphogenesis
GO:3281; ventricular septum development
GO:6955; immune response
GO:7352; zygotic specification of dorsal/ventral axis
GO:10991; negative regulation of SMAD protein complex assembly
GO:30279; negative regulation of ossification
GO:31589; cell-substrate adhesion
GO:32496; response to lipopolysaccharide
GO:35904; aorta development
GO:43627; response to estrogen
GO:45668; negative regulation of osteoblast differentiation
GO:60976; coronary vasculature development
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:16604; nuclear body
GO:5667; transcription regulator complex
GO:785; chromatin
GO:32991; protein-containing complex
GO:71144; heteromeric SMAD protein complex
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:976; transcription cis-regulatory region binding
GO:3682; chromatin binding
GO:70412; R-SMAD binding
GO:70410; co-SMAD binding
GO:31625; ubiquitin protein ligase binding
GO:34713; type I transforming growth factor beta receptor binding
GO:70411; I-SMAD binding
GO:140416; transcription regulator inhibitor activity
GO:70698; type I activin receptor binding
Hide GO terms

Homologs of SMAD6 in Model Organisms

Danio rerio
smad6b
Mus musculus
Smad6
Rattus norvegicus
Smad6

External links

OMIM
602931
Ensembl
ENSG00000137834
Entrez Gene
4091
UniGene
153863
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMAD6
GeneCards
SMAD6