Cell Senescence Entries for SMARCA2

Cell Types
Lung cancer
Cell Lines
H1299
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Oike et al. (2013) A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1. Cancer Res 73(17)5508-18 (PubMed)

SMARCA2 Gene Information

HGNC symbol
SMARCA2 
Aliases
BAF190; BRM; hBRM; hSNF2a; SNF2; SNF2L2; SNF2LA; Sth1p; SWI2 
Common name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 
Entrez Id
6595
Description
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014].

SMARCA2 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:7399; nervous system development
GO:8285; negative regulation of cell population proliferation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II
GO:45892; negative regulation of transcription, DNA-templated
GO:6338; chromatin remodeling
GO:30308; negative regulation of cell growth
GO:2000045; regulation of G1/S transition of mitotic cell cycle
GO:2000781; positive regulation of double-strand break repair
GO:30071; regulation of mitotic metaphase/anaphase transition
GO:45582; positive regulation of T cell differentiation
GO:45597; positive regulation of cell differentiation
GO:45663; positive regulation of myoblast differentiation
GO:70316; regulation of G0 to G1 transition
GO:1902459; positive regulation of stem cell population maintenance
GO:2000819; regulation of nucleotide-excision repair
GO:8284; positive regulation of cell population proliferation
GO:45596; negative regulation of cell differentiation
GO:6325; chromatin organization
GO:7286; spermatid development
Cellular component: GO:5634; nucleus
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:45111; intermediate filament cytoskeleton
GO:16514; SWI/SNF complex
GO:785; chromatin
GO:71564; npBAF complex
GO:71565; nBAF complex
GO:35060; brahma complex
GO:140092; bBAF complex
GO:140288; GBAF complex
GO:70603; SWI/SNF superfamily-type complex
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3677; DNA binding
GO:16787; hydrolase activity
GO:4386; helicase activity
GO:16887; ATP hydrolysis activity
GO:42393; histone binding
GO:3713; transcription coactivator activity
GO:976; transcription cis-regulatory region binding
GO:8094; ATPase, acting on DNA
GO:140658; ATP-dependent chromatin remodeler activity
GO:3682; chromatin binding
Hide GO terms

Homologs of SMARCA2 in Model Organisms

Danio rerio
smarca2
Drosophila melanogaster
brm
Mus musculus
Smarca2
Rattus norvegicus
Smarca2
Saccharomyces cerevisiae
SNF2

External links

OMIM
600014
Ensembl
ENSG00000080503
Entrez Gene
6595
UniGene
644901
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMARCA2
GeneCards
SMARCA2