Cell Senescence Entries for SNAI1

Cell Types
Prostate cancer
Cell Lines
LNCaP, PC-3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Emadi Baygi et al. (2010) Snail regulates cell survival and inhibits cellular senescence in human metastatic prostate cancer cell lines. Cell Biol Toxicol 26(6)553-67 (PubMed)

SNAI1 Gene Information

HGNC symbol
SNAI1 
Aliases
SLUGH2; SNA; SNAH; SNAIL; SNAIL1 
Common name
snail family transcriptional repressor 1 
Entrez Id
6615
Description
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008].

SNAI1 Ontologies

Gene Ontology
Process: GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II
GO:30335; positive regulation of cell migration
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:3180; aortic valve morphogenesis
GO:1649; osteoblast differentiation
GO:3198; epithelial to mesenchymal transition involved in endocardial cushion formation
GO:10957; negative regulation of vitamin D biosynthetic process
GO:43518; negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:61314; Notch signaling involved in heart development
GO:1902230; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000810; regulation of bicellular tight junction assembly
GO:1707; mesoderm formation
GO:1837; epithelial to mesenchymal transition
GO:7498; mesoderm development
GO:16477; cell migration
GO:31069; hair follicle morphogenesis
GO:45892; negative regulation of transcription, DNA-templated
GO:60021; roof of mouth development
GO:60536; cartilage morphogenesis
GO:60707; trophoblast giant cell differentiation
GO:60806; negative regulation of cell differentiation involved in embryonic placenta development
GO:60972; left/right pattern formation
GO:70828; heterochromatin organization
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:1650; fibrillar center
GO:5721; pericentric heterochromatin
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:5515; protein binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3700; DNA-binding transcription factor activity
GO:1990837; sequence-specific double-stranded DNA binding
GO:70888; E-box binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:19900; kinase binding
GO:43565; sequence-specific DNA binding
Hide GO terms

Homologs of SNAI1 in Model Organisms

Mus musculus
Snai1
Rattus norvegicus
Snai1

External links

OMIM
604238
Ensembl
ENSG00000124216
Entrez Gene
6615
UniGene
48029
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SNAI1
GeneCards
SNAI1