The SOD1 gene and its putative association with human ageing

Cell Senescence Entries for SOD1

Cell Types: Lung fibroblast
Cell Lines: WI-38, WI38-SV40
Cancer Cell?: No
Method: Knockdown
Type of senescence: Unclear
Senescence Effect: Inhibits
Primary Reference: Blander et al. (2003) Superoxide dismutase 1 knock-down induces senescence in human fibroblasts. J Biol Chem 278(40)38966-9 (PubMed)

SOD1 Gene Information

HGNC symbol: SOD1
Aliases: ALS; ALS1; IPOA
Common name: superoxide dismutase 1
Entrez Id: 6647
Description: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020].

SOD1 Ontologies

Gene Ontology

Process:

GO:6801; superoxide metabolic process
GO:19430; removal of superoxide radicals
GO:7605; sensory perception of sound
GO:43065; positive regulation of apoptotic process
GO:6879; cellular iron ion homeostasis
GO:10033; response to organic substance
GO:7283; spermatogenesis
GO:6749; glutathione metabolic process
GO:43085; positive regulation of catalytic activity
GO:72593; reactive oxygen species metabolic process
GO:1890; placenta development
GO:60088; auditory receptor cell stereocilium organization
GO:1895; retina homeostasis
GO:1819; positive regulation of cytokine production
GO:43410; positive regulation of MAPK cascade
GO:7566; embryo implantation
GO:43087; regulation of GTPase activity
GO:8217; regulation of blood pressure
GO:43524; negative regulation of neuron apoptotic process
GO:48538; thymus development
GO:42542; response to hydrogen peroxide
GO:9408; response to heat
GO:45859; regulation of protein kinase activity
GO:7569; cell aging
GO:7626; locomotory behavior
GO:45541; negative regulation of cholesterol biosynthetic process
GO:51881; regulation of mitochondrial membrane potential
GO:46716; muscle cell cellular homeostasis
GO:302; response to reactive oxygen species
GO:303; response to superoxide
GO:1541; ovarian follicle development
GO:1975; response to amphetamine
GO:2262; myeloid cell homeostasis
GO:6979; response to oxidative stress
GO:7568; aging
GO:8089; anterograde axonal transport
GO:8090; retrograde axonal transport
GO:9410; response to xenobiotic stimulus
GO:19226; transmission of nerve impulse
GO:31667; response to nutrient levels
GO:32287; peripheral nervous system myelin maintenance
GO:32930; positive regulation of superoxide anion generation
GO:33081; regulation of T cell differentiation in thymus
GO:34465; response to carbon monoxide
GO:34599; cellular response to oxidative stress
GO:35865; cellular response to potassium ion
GO:40014; regulation of multicellular organism growth
GO:42554; superoxide anion generation
GO:43066; negative regulation of apoptotic process
GO:45471; response to ethanol
GO:46620; regulation of organ growth
GO:46677; response to antibiotic
GO:46688; response to copper ion
GO:48678; response to axon injury
GO:50665; hydrogen peroxide biosynthetic process
GO:50728; negative regulation of inflammatory response
GO:50766; positive regulation of phagocytosis
GO:60047; heart contraction
GO:60052; neurofilament cytoskeleton organization
GO:60087; relaxation of vascular associated smooth muscle
GO:71276; cellular response to cadmium ion
GO:71318; cellular response to ATP
GO:97332; response to antipsychotic drug
GO:1902177; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular component:

GO:5654; nucleoplasm
GO:5829; cytosol
GO:5634; nucleus
GO:5737; cytoplasm
GO:31410; cytoplasmic vesicle
GO:32991; protein-containing complex
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:5615; extracellular space
GO:1904115; axon cytoplasm
GO:5777; peroxisome
GO:5576; extracellular region
GO:70062; extracellular exosome
GO:5758; mitochondrial intermembrane space
GO:43025; neuronal cell body
GO:5764; lysosome
GO:30141; secretory granule
GO:31045; dense core granule
GO:32839; dendrite cytoplasm
GO:43005; neuron projection

Function:

GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:4784; superoxide dismutase activity
GO:8270; zinc ion binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:16209; antioxidant activity
GO:5507; copper ion binding
GO:31267; small GTPase binding
GO:51087; chaperone binding
GO:19899; enzyme binding
GO:30346; protein phosphatase 2B binding

Hide GO terms

Homologs of SOD1 in Model Organisms

Caenorhabditis elegans: sod-5
Danio rerio: sod1
Drosophila melanogaster: Sod
Mus musculus: Sod1
Rattus norvegicus: Sod1
Saccharomyces cerevisiae: SOD1
Schizosaccharomyces pombe: sod1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
A homolog of this gene for Drosophila melanogaster is present as Sod

GenAge human genes

This gene is present as SOD1

GenDR gene manipulations

A homolog of this gene for Saccharomyces cerevisiae is present as SOD1

LongevityMap

This gene is present as SOD1

Cell Senescence Entries for SOD1

SOD1 Gene Information

SOD1 Ontologies

Homologs of SOD1 in Model Organisms

In other databases

External links