Cell Senescence Entries for SORBS2

Cell Types
Fibroblast, Keratinocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Liesenfeld et al. (2014) SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes. BMC Cancer 13(2)507 (PubMed)

SORBS2 Gene Information

HGNC symbol
SORBS2 
Aliases
ARGBP2; KIAA0777 
Common name
sorbin and SH3 domain containing 2 
Entrez Id
8470
Description
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

SORBS2 Ontologies

Gene Ontology
Process: GO:7015; actin filament organization
GO:8150; biological_process
GO:7219; Notch signaling pathway
GO:61049; cell growth involved in cardiac muscle cell development
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5925; focal adhesion
GO:5634; nucleus
GO:5886; plasma membrane
GO:30054; cell junction
GO:16324; apical plasma membrane
GO:42995; cell projection
GO:48471; perinuclear region of cytoplasm
GO:30027; lamellipodium
GO:30018; Z disc
GO:45202; synapse
GO:43025; neuronal cell body
GO:30425; dendrite
GO:15629; actin cytoskeleton
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:5200; structural constituent of cytoskeleton
GO:8307; structural constituent of muscle
GO:8093; cytoskeletal anchor activity
GO:42802; identical protein binding
Hide GO terms

Homologs of SORBS2 in Model Organisms

Danio rerio
sorbs2b
Mus musculus
Sorbs2
Rattus norvegicus
Sorbs2

External links

OMIM
616349
Ensembl
ENSG00000154556
Entrez Gene
8470
UniGene
619806
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SORBS2
GeneCards
SORBS2