Cell Senescence Entries for SOX2

Cell Types
Colon cancer, Embryonic kidney
Cell Lines
HCT116, HEK293T, WiDr
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Cho et al. (2013) Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells. PLoS One 8(2)e57172 (PubMed)

SOX2 Gene Information

HGNC symbol
SOX2 
Aliases
 
Common name
SRY-box transcription factor 2 
Entrez Id
6657
Description
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008].

SOX2 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:10468; regulation of gene expression
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:48731; system development
GO:21984; adenohypophysis development
GO:22409; positive regulation of cell-cell adhesion
GO:42246; tissue regeneration
GO:45597; positive regulation of cell differentiation
GO:30154; cell differentiation
GO:9653; anatomical structure morphogenesis
GO:1654; eye development
GO:43410; positive regulation of MAPK cascade
GO:1902807; negative regulation of cell cycle G1/S phase transition
GO:45665; negative regulation of neuron differentiation
GO:97150; neuronal stem cell population maintenance
GO:45165; cell fate commitment
GO:50680; negative regulation of epithelial cell proliferation
GO:1649; osteoblast differentiation
GO:9611; response to wounding
GO:21983; pituitary gland development
GO:48839; inner ear development
GO:70848; response to growth factor
GO:35019; somatic stem cell population maintenance
GO:30900; forebrain development
GO:1714; endodermal cell fate specification
GO:21781; glial cell fate commitment
GO:43281; regulation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:5667; transcription regulator complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
GO:35198; miRNA binding
Hide GO terms

Homologs of SOX2 in Model Organisms

Danio rerio
sox2
Drosophila melanogaster
SoxN
Mus musculus
Sox2
Rattus norvegicus
Sox2

External links

OMIM
184429
Ensembl
ENSG00000181449
Entrez Gene
6657
UniGene
732963
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SOX2
GeneCards
SOX2