Cell Senescence Entries for SOX4

Cell Types
Squamous carcinoma
Cell Lines
KYSE-410, KYSE-510
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Han et al. (2020) Upregulation of SOX4 antagonizes cellular senescence in esophageal squamous cell carcinoma. Oncol Lett 12(2)1367-1372 (PubMed)

SOX4 Gene Information

HGNC symbol
SOX4 
Aliases
 
Common name
SRY-box transcription factor 4 
Entrez Id
6659
Description
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008].

SOX4 Ontologies

Gene Ontology
Process: GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:8285; negative regulation of cell population proliferation
GO:30154; cell differentiation
GO:9653; anatomical structure morphogenesis
GO:1501; skeletal system development
GO:6355; regulation of transcription, DNA-templated
GO:8284; positive regulation of cell population proliferation
GO:31647; regulation of protein stability
GO:21510; spinal cord development
GO:45727; positive regulation of translation
GO:43065; positive regulation of apoptotic process
GO:50821; protein stabilization
GO:31397; negative regulation of protein ubiquitination
GO:7507; heart development
GO:60412; ventricular septum morphogenesis
GO:42593; glucose homeostasis
GO:3183; mitral valve morphogenesis
GO:60548; negative regulation of cell death
GO:32024; positive regulation of insulin secretion
GO:48485; sympathetic nervous system development
GO:45663; positive regulation of myoblast differentiation
GO:71333; cellular response to glucose stimulus
GO:60174; limb bud formation
GO:1841; neural tube formation
GO:3211; cardiac ventricle formation
GO:3357; noradrenergic neuron differentiation
GO:14009; glial cell proliferation
GO:21782; glial cell development
GO:60563; neuroepithelial cell differentiation
GO:3215; cardiac right ventricle morphogenesis
GO:3289; atrial septum primum morphogenesis
GO:45588; positive regulation of gamma-delta T cell differentiation
GO:35910; ascending aorta morphogenesis
GO:2328; pro-B cell differentiation
GO:21522; spinal cord motor neuron differentiation
GO:30217; T cell differentiation
GO:31018; endocrine pancreas development
GO:35019; somatic stem cell population maintenance
GO:43516; regulation of DNA damage response, signal transduction by p53 class mediator
GO:60993; kidney morphogenesis
GO:61484; hematopoietic stem cell homeostasis
GO:2000761; positive regulation of N-terminal peptidyl-lysine acetylation
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:785; chromatin
GO:5667; transcription regulator complex
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:35198; miRNA binding
Hide GO terms

Homologs of SOX4 in Model Organisms

Danio rerio
sox4a
Mus musculus
Sox4

In other databases

CellAge gene expression
  • This gene is present as SOX4

External links

OMIM
184430
Ensembl
ENSG00000124766
Entrez Gene
6659
UniGene
643910
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SOX4
GeneCards
SOX4