Cell Senescence Entries for SPARC
- Cell Types
- Colon cancer
- Cell Lines
- MIP-101
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Chan et al. (2010) Secreted protein acidic and rich in cysteine-induced cellular senescence in colorectal cancers in response to irinotecan is mediated by P53. Carcinogenesis 31(5)812-9 (PubMed)
SPARC Gene Information
- HGNC symbol
- SPARC
- Aliases
- BM-40; ON; ONT
- Common name
- secreted protein acidic and cysteine rich
- Entrez Id
- 6678
- Description
- This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015].
SPARC Ontologies
- Gene Ontology
-
Process: GO:22604; regulation of cell morphogenesis
GO:16525; negative regulation of angiogenesis
GO:48856; anatomical structure development
GO:1937; negative regulation of endothelial cell proliferation
GO:10595; positive regulation of endothelial cell migration
Cellular component: GO:5737; cytoplasm
GO:5615; extracellular space
GO:43231; intracellular membrane-bounded organelle
GO:5576; extracellular region
GO:9986; cell surface
GO:5604; basement membrane
GO:62023; collagen-containing extracellular matrix
GO:5886; plasma membrane
GO:16363; nuclear matrix
GO:31091; platelet alpha granule
GO:31093; platelet alpha granule lumen
GO:71682; endocytic vesicle lumen
GO:31092; platelet alpha granule membrane
GO:16020; membrane
Hide GO termsFunction: GO:5515; protein binding
GO:46872; metal ion binding
GO:5509; calcium ion binding
GO:5518; collagen binding
GO:50840; extracellular matrix binding
GO:5201; extracellular matrix structural constituent
Homologs of SPARC in Model Organisms
- Caenorhabditis elegans
- ost-1
- Danio rerio
- sparc
- Drosophila melanogaster
- BM-40-SPARC
- Mus musculus
- Sparc
- Rattus norvegicus
- Sparc
In other databases
- CellAge gene expression
- This gene is present as SPARC
External links
- OMIM
- 182120
- Ensembl
- ENSG00000113140
- Entrez Gene
- 6678
- UniGene
- 111779
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SPARC
- GeneCards
- SPARC