Cell Senescence Entries for SPHK1

Cell Types
Adipose-derived stromal cell
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2019) Links between accelerated replicative cellular senescence and down-regulation of SPHK1 transcription. BMB Rep 52(3)220-225 (PubMed)

SPHK1 Gene Information

HGNC symbol
SPHK1 
Aliases
SPHK 
Common name
sphingosine kinase 1 
Entrez Id
8877
Description
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017].

SPHK1 Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:6629; lipid metabolic process
GO:30100; regulation of endocytosis
GO:46834; lipid phosphorylation
GO:35556; intracellular signal transduction
GO:6473; protein acetylation
GO:3376; sphingosine-1-phosphate receptor signaling pathway
GO:31398; positive regulation of protein ubiquitination
GO:10800; positive regulation of peptidyl-threonine phosphorylation
GO:30335; positive regulation of cell migration
GO:46512; sphingosine biosynthetic process
GO:19722; calcium-mediated signaling
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:1901224; positive regulation of NIK/NF-kappaB signaling
GO:71363; cellular response to growth factor stimulus
GO:30307; positive regulation of cell growth
GO:6670; sphingosine metabolic process
GO:30148; sphingolipid biosynthetic process
GO:45766; positive regulation of angiogenesis
GO:35924; cellular response to vascular endothelial growth factor stimulus
GO:34612; response to tumor necrosis factor
GO:32740; positive regulation of interleukin-17 production
GO:1900745; positive regulation of p38MAPK cascade
GO:50764; regulation of phagocytosis
GO:45931; positive regulation of mitotic cell cycle
GO:45987; positive regulation of smooth muscle contraction
GO:150077; regulation of neuroinflammatory response
GO:48146; positive regulation of fibroblast proliferation
GO:6665; sphingolipid metabolic process
GO:10803; regulation of tumor necrosis factor-mediated signaling pathway
GO:46521; sphingoid catabolic process
GO:1900060; negative regulation of ceramide biosynthetic process
GO:1903978; regulation of microglial cell activation
GO:1905364; regulation of endosomal vesicle fusion
GO:1568; blood vessel development
GO:6954; inflammatory response
GO:7420; brain development
GO:8284; positive regulation of cell population proliferation
GO:32651; regulation of interleukin-1 beta production
GO:45840; positive regulation of mitotic nuclear division
GO:70301; cellular response to hydrogen peroxide
GO:71897; DNA biosynthetic process
GO:90520; sphingolipid mediated signaling pathway
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5905; clathrin-coated pit
GO:5829; cytosol
GO:5886; plasma membrane
GO:5768; endosome
GO:30054; cell junction
GO:10008; endosome membrane
GO:45202; synapse
GO:31901; early endosome membrane
GO:43231; intracellular membrane-bounded organelle
GO:98793; presynapse
GO:30139; endocytic vesicle
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:3951; NAD+ kinase activity
GO:5515; protein binding
GO:8289; lipid binding
GO:287; magnesium ion binding
GO:5516; calmodulin binding
GO:3677; DNA binding
GO:38036; sphingosine-1-phosphate receptor activity
GO:16407; acetyltransferase activity
GO:1727; lipid kinase activity
GO:51721; protein phosphatase 2A binding
GO:8481; sphinganine kinase activity
GO:17050; D-erythro-sphingosine kinase activity
Hide GO terms

Homologs of SPHK1 in Model Organisms

Danio rerio
sphk2
Mus musculus
Sphk1
Rattus norvegicus
Sphk1
Saccharomyces cerevisiae
LCB5

In other databases

CellAge gene expression
  • This gene is present as SPHK1

External links

OMIM
603730
Ensembl
ENSG00000176170
Entrez Gene
8877
UniGene
68061
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SPHK1
GeneCards
SPHK1