The SPI1 gene and its putative association with human ageing

Cell Types

Foreskin fibroblast, Hematopoietic stem progenitor, Lung fibroblast

Cell Lines

BJ, Primary cell, WI-38

Cancer Cell?

No

Method

Overexpression

Type of senescence

Oncogene-induced

Senescence Effect

Induces

Primary Reference

Delestré et al. (2018) Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells. Haematologica 102(11)1850-1860 (PubMed)

HGNC symbol

SPI1

Aliases

OF; PU.1; SFPI1; SPI-1; SPI-A

Common name

Spi-1 proto-oncogene

Entrez Id

6688

Description

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Process:

GO:10629; negative regulation of gene expression
GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45892; negative regulation of transcription, DNA-templated
GO:43966; histone H3 acetylation
GO:30154; cell differentiation
GO:122; negative regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:2357; defense response to tumor cell
GO:45814; negative regulation of gene expression, epigenetic
GO:1900745; positive regulation of p38MAPK cascade
GO:70102; interleukin-6-mediated signaling pathway
GO:36462; TRAIL-activated apoptotic signaling pathway
GO:1944; vasculature development
GO:2314; germinal center B cell differentiation
GO:2316; follicular B cell differentiation
GO:2320; lymphoid progenitor cell differentiation
GO:2327; immature B cell differentiation
GO:2572; pro-T cell differentiation
GO:2573; myeloid leukocyte differentiation
GO:7179; transforming growth factor beta receptor signaling pathway
GO:10628; positive regulation of gene expression
GO:30098; lymphocyte differentiation
GO:30218; erythrocyte differentiation
GO:30225; macrophage differentiation
GO:30851; granulocyte differentiation
GO:31663; lipopolysaccharide-mediated signaling pathway
GO:32088; negative regulation of NF-kappaB transcription factor activity
GO:35019; somatic stem cell population maintenance
GO:43011; myeloid dendritic cell differentiation
GO:43314; negative regulation of neutrophil degranulation
GO:44027; hypermethylation of CpG island
GO:45347; negative regulation of MHC class II biosynthetic process
GO:45646; regulation of erythrocyte differentiation
GO:45893; positive regulation of transcription, DNA-templated
GO:51090; regulation of DNA-binding transcription factor activity
GO:60033; anatomical structure regression
GO:90241; negative regulation of histone H4 acetylation
GO:90402; oncogene-induced cell senescence
GO:98508; endothelial to hematopoietic transition
GO:120186; negative regulation of protein localization to chromatin
GO:1901223; negative regulation of NIK/NF-kappaB signaling
GO:1901674; regulation of histone H3-K27 acetylation
GO:1902262; apoptotic process involved in blood vessel morphogenesis
GO:1904151; positive regulation of microglial cell mediated cytotoxicity
GO:1904178; negative regulation of adipose tissue development
GO:1904238; pericyte cell differentiation
GO:1905036; positive regulation of antifungal innate immune response
GO:1905453; regulation of myeloid progenitor cell differentiation
GO:2000529; positive regulation of myeloid dendritic cell chemotaxis

Cellular component:

GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:5667; transcription regulator complex
GO:16020; membrane
GO:16021; integral component of membrane

Function:

GO:3723; RNA binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:97677; STAT family protein binding
GO:140297; DNA-binding transcription factor binding
GO:1216; DNA-binding transcription activator activity
GO:987; cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:1217; DNA-binding transcription repressor activity
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:3682; chromatin binding
GO:42826; histone deacetylase binding
GO:51525; NFAT protein binding
GO:140311; protein sequestering activity

Hide GO terms

Danio rerio

Mus musculus

Rattus norvegicus

OMIM

Ensembl

Entrez Gene