The SRC gene and its putative association with human ageing

Cell Types

Fibrosarcoma

Cell Lines

HT1080

Cancer Cell?

Yes

Method

Overexpression

Type of senescence

Stress-induced

Senescence Effect

Inhibits

Primary Reference

Vigneron et al. (2005) Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1. Cancer Res 65(19)8927-35 (PubMed)

HGNC symbol

SRC

Aliases

ASV; c-src; SRC1

Common name

SRC proto-oncogene, non-receptor tyrosine kinase

Entrez Id

6714

Description

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Process:

GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:7155; cell adhesion
GO:2376; immune system process
GO:7229; integrin-mediated signaling pathway
GO:45087; innate immune response
GO:46777; protein autophosphorylation
GO:51897; positive regulation of protein kinase B signaling
GO:30154; cell differentiation
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:2000641; regulation of early endosome to late endosome transport
GO:51902; negative regulation of mitochondrial depolarization
GO:43149; stress fiber assembly
GO:7165; signal transduction
GO:48041; focal adhesion assembly
GO:30168; platelet activation
GO:7179; transforming growth factor beta receptor signaling pathway
GO:45747; positive regulation of Notch signaling pathway
GO:31333; negative regulation of protein-containing complex assembly
GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001243; negative regulation of intrinsic apoptotic signaling pathway
GO:35556; intracellular signal transduction
GO:45453; bone resorption
GO:2223; stimulatory C-type lectin receptor signaling pathway
GO:38096; Fc-gamma receptor signaling pathway involved in phagocytosis
GO:7173; epidermal growth factor receptor signaling pathway
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway
GO:10634; positive regulation of epithelial cell migration
GO:50731; positive regulation of peptidyl-tyrosine phosphorylation
GO:51895; negative regulation of focal adhesion assembly
GO:70555; response to interleukin-1
GO:33625; positive regulation of integrin activation
GO:48013; ephrin receptor signaling pathway
GO:16236; macroautophagy
GO:70102; interleukin-6-mediated signaling pathway
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:10632; regulation of epithelial cell migration
GO:18108; peptidyl-tyrosine phosphorylation
GO:51974; negative regulation of telomerase activity
GO:45124; regulation of bone resorption
GO:2000811; negative regulation of anoikis
GO:31295; T cell costimulation
GO:50900; leukocyte migration
GO:2862; negative regulation of inflammatory response to antigenic stimulus
GO:48010; vascular endothelial growth factor receptor signaling pathway
GO:7172; signal complex assembly
GO:32211; negative regulation of telomere maintenance via telomerase
GO:43114; regulation of vascular permeability
GO:22407; regulation of cell-cell adhesion
GO:2000394; positive regulation of lamellipodium morphogenesis
GO:1545; primary ovarian follicle growth
GO:1819; positive regulation of cytokine production
GO:8283; cell population proliferation
GO:9410; response to xenobiotic stimulus
GO:9612; response to mechanical stimulus
GO:9615; response to virus
GO:10447; response to acidic pH
GO:10628; positive regulation of gene expression
GO:10641; positive regulation of platelet-derived growth factor receptor signaling pathway
GO:10907; positive regulation of glucose metabolic process
GO:10954; positive regulation of protein processing
GO:14911; positive regulation of smooth muscle cell migration
GO:16477; cell migration
GO:18105; peptidyl-serine phosphorylation
GO:30900; forebrain development
GO:31648; protein destabilization
GO:31667; response to nutrient levels
GO:31954; positive regulation of protein autophosphorylation
GO:32148; activation of protein kinase B activity
GO:32869; cellular response to insulin stimulus
GO:33146; regulation of intracellular estrogen receptor signaling pathway
GO:34332; adherens junction organization
GO:34446; substrate adhesion-dependent cell spreading
GO:34614; cellular response to reactive oxygen species
GO:35306; positive regulation of dephosphorylation
GO:35635; entry of bacterium into host cell
GO:36035; osteoclast development
GO:36120; cellular response to platelet-derived growth factor stimulus
GO:38083; peptidyl-tyrosine autophosphorylation
GO:38128; ERBB2 signaling pathway
GO:42476; odontogenesis
GO:42542; response to hydrogen peroxide
GO:43065; positive regulation of apoptotic process
GO:43393; regulation of protein binding
GO:43406; positive regulation of MAP kinase activity
GO:43552; positive regulation of phosphatidylinositol 3-kinase activity
GO:45056; transcytosis
GO:45737; positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:45785; positive regulation of cell adhesion
GO:45892; negative regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:46628; positive regulation of insulin receptor signaling pathway
GO:48011; neurotrophin TRK receptor signaling pathway
GO:48477; oogenesis
GO:50847; progesterone receptor signaling pathway
GO:51057; positive regulation of small GTPase mediated signal transduction
GO:51222; positive regulation of protein transport
GO:51385; response to mineralocorticoid
GO:51602; response to electrical stimulus
GO:60065; uterus development
GO:60444; branching involved in mammary gland duct morphogenesis
GO:60491; regulation of cell projection assembly
GO:60576; intestinal epithelial cell development
GO:70301; cellular response to hydrogen peroxide
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:70542; response to fatty acid
GO:71222; cellular response to lipopolysaccharide
GO:71375; cellular response to peptide hormone stimulus
GO:71393; cellular response to progesterone stimulus
GO:71398; cellular response to fatty acid
GO:71456; cellular response to hypoxia
GO:71498; cellular response to fluid shear stress
GO:71560; cellular response to transforming growth factor beta stimulus
GO:71803; positive regulation of podosome assembly
GO:86098; angiotensin-activated signaling pathway involved in heart process
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:98609; cell-cell adhesion
GO:98962; regulation of postsynaptic neurotransmitter receptor activity
GO:1900182; positive regulation of protein localization to nucleus
GO:1902533; positive regulation of intracellular signal transduction
GO:1903997; positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:2000386; positive regulation of ovarian follicle development
GO:2000573; positive regulation of DNA biosynthetic process
GO:2000588; positive regulation of platelet-derived growth factor receptor-beta signaling pathway
GO:2001286; regulation of caveolin-mediated endocytosis

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5770; late endosome
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:30054; cell junction
GO:5764; lysosome
GO:48471; perinuclear region of cytoplasm
GO:31234; extrinsic component of cytoplasmic side of plasma membrane
GO:70062; extracellular exosome
GO:45121; membrane raft
GO:5901; caveola
GO:2102; podosome
GO:5884; actin filament
GO:14069; postsynaptic density
GO:32587; ruffle membrane
GO:43005; neuron projection
GO:98978; glutamatergic synapse
GO:99091; postsynaptic specialization, intracellular component

Function:

GO:5524; ATP binding
GO:5515; protein binding
GO:4672; protein kinase activity
GO:4713; protein tyrosine kinase activity
GO:166; nucleotide binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:4715; non-membrane spanning protein tyrosine kinase activity
GO:5102; signaling receptor binding
GO:19899; enzyme binding
GO:20037; heme binding
GO:45296; cadherin binding
GO:42169; SH2 domain binding
GO:44325; transmembrane transporter binding
GO:5178; integrin binding
GO:51219; phosphoprotein binding
GO:97110; scaffold protein binding
GO:70851; growth factor receptor binding
GO:19900; kinase binding
GO:51117; ATPase binding
GO:8022; protein C-terminus binding
GO:16004; phospholipase activator activity
GO:43274; phospholipase binding
GO:46875; ephrin receptor binding
GO:5080; protein kinase C binding
GO:5158; insulin receptor binding
GO:19901; protein kinase binding
GO:19904; protein domain specific binding
GO:30331; estrogen receptor binding
GO:44877; protein-containing complex binding
GO:50839; cell adhesion molecule binding
GO:70700; BMP receptor binding
GO:71253; connexin binding

Hide GO terms

Danio rerio

Mus musculus

Rattus norvegicus

OMIM

Ensembl

Entrez Gene