Cell Senescence Entries for SREBF1

Cell Types
Cervical cancer, Fibroblast
Cell Lines
HeLa, Primary cell
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Kim et al. (2014) Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells. Endocrinol Metab (Seoul) 28(4)297-308 (PubMed)
Cell Types
Cervical cancer, Fibroblast
Cell Lines
HeLa, Primary cell
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Kim et al. (2010) Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence. J Biol Chem 285(38)29069-77 (PubMed)

SREBF1 Gene Information

HGNC symbol
SREBF1 
Aliases
bHLHd1; SREBP-1c; SREBP1; SREBP1a 
Common name
sterol regulatory element binding transcription factor 1 
Entrez Id
6720
Description
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017].

SREBF1 Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:8202; steroid metabolic process
GO:8203; cholesterol metabolic process
GO:30522; intracellular receptor signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1903146; regulation of autophagy of mitochondrion
GO:1903214; regulation of protein targeting to mitochondrion
GO:31647; regulation of protein stability
GO:8610; lipid biosynthetic process
GO:10867; positive regulation of triglyceride biosynthetic process
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:9267; cellular response to starvation
GO:32933; SREBP signaling pathway
GO:122; negative regulation of transcription by RNA polymerase II
GO:3062; regulation of heart rate by chemical signal
GO:6355; regulation of transcription, DNA-templated
GO:7568; aging
GO:7623; circadian rhythm
GO:8286; insulin receptor signaling pathway
GO:9410; response to xenobiotic stimulus
GO:9749; response to glucose
GO:10876; lipid localization
GO:10883; regulation of lipid storage
GO:14070; response to organic cyclic compound
GO:19217; regulation of fatty acid metabolic process
GO:30324; lung development
GO:31065; positive regulation of histone deacetylation
GO:32094; response to food
GO:32526; response to retinoic acid
GO:32570; response to progesterone
GO:32869; cellular response to insulin stimulus
GO:33762; response to glucagon
GO:33993; response to lipid
GO:42789; mRNA transcription by RNA polymerase II
GO:43434; response to peptide hormone
GO:45444; fat cell differentiation
GO:45471; response to ethanol
GO:45542; positive regulation of cholesterol biosynthetic process
GO:45893; positive regulation of transcription, DNA-templated
GO:46676; negative regulation of insulin secretion
GO:50796; regulation of insulin secretion
GO:51591; response to cAMP
GO:70542; response to fatty acid
GO:71398; cellular response to fatty acid
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:12507; ER to Golgi transport vesicle membrane
GO:139; Golgi membrane
GO:785; chromatin
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5635; nuclear envelope
GO:32991; protein-containing complex
GO:43231; intracellular membrane-bounded organelle
Function: GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:3700; DNA-binding transcription factor activity
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:1221; transcription coregulator binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:4879; nuclear receptor activity
GO:32810; sterol response element binding
GO:3682; chromatin binding
GO:19901; protein kinase binding
GO:43565; sequence-specific DNA binding
GO:44877; protein-containing complex binding
Hide GO terms

Homologs of SREBF1 in Model Organisms

Danio rerio
srebf1
Mus musculus
Srebf1
Rattus norvegicus
Srebf1

In other databases

GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Srebf1
LongevityMap
  • This gene is present as SREBF1

External links

OMIM
184756
Ensembl
ENSG00000072310
Entrez Gene
6720
UniGene
733635
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SREBF1
GeneCards
SREBF1