The SSX2 gene and its putative association with human ageing

Cell Senescence Entries for SSX2

Cell Types: Breast cancer
Cell Lines: MCF-7
Cancer Cell?: Yes
Method: Overexpression
Type of senescence: Oncogene-induced
Senescence Effect: Induces
Primary Reference: Greve et al. (2015) Ectopic expression of cancer/testis antigen SSX2 induces DNA damage and promotes genomic instability. Mol Oncol 9(2)437-49 (PubMed)

HGNC symbol: SSX2
Aliases: CT5.2a; HD21; HOM-MEL-40; MGC119055; MGC15364; MGC3884; SSX
Common name: SSX family member 2
Entrez Id: 6757
Description: The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013].

Gene Ontology

Process:

GO:6355; regulation of transcription, DNA-templated

Cellular component:

GO:5634; nucleus

Function:

GO:5515; protein binding

Hide GO terms

No homologs found