The STAT1 gene and its putative association with human ageing

Cell Types

Glomerular mesangial cell

Cell Lines

Primary cell

Cancer Cell?

No

Method

Knockdown

Type of senescence

Unclear

Senescence Effect

Induces

Primary Reference

Jiao et al. (2012) Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin II induced premature senescence. Can J Physiol Pharmacol 90(1)89-98 (PubMed)

HGNC symbol

STAT1

Aliases

ISGF-3; STAT91

Common name

signal transducer and activator of transcription 1

Entrez Id

6772

Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020].

Gene Ontology

Process:

GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:19221; cytokine-mediated signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:51607; defense response to virus
GO:8015; blood circulation
GO:33209; tumor necrosis factor-mediated signaling pathway
GO:60333; interferon-gamma-mediated signaling pathway
GO:60337; type I interferon signaling pathway
GO:42981; regulation of apoptotic process
GO:6952; defense response
GO:71346; cellular response to interferon-gamma
GO:16525; negative regulation of angiogenesis
GO:42127; regulation of cell population proliferation
GO:1937; negative regulation of endothelial cell proliferation
GO:32727; positive regulation of interferon-alpha production
GO:43124; negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:2230; positive regulation of defense response to virus by host
GO:48661; positive regulation of smooth muscle cell proliferation
GO:35456; response to interferon-beta
GO:51591; response to cAMP
GO:2053; positive regulation of mesenchymal cell proliferation
GO:72162; metanephric mesenchymal cell differentiation
GO:7259; receptor signaling pathway via JAK-STAT
GO:34097; response to cytokine
GO:46725; negative regulation by virus of viral protein levels in host cell
GO:45648; positive regulation of erythrocyte differentiation
GO:70106; interleukin-27-mediated signaling pathway
GO:35458; cellular response to interferon-beta
GO:43434; response to peptide hormone
GO:10742; macrophage derived foam cell differentiation
GO:3340; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:61326; renal tubule development
GO:72136; metanephric mesenchymal cell proliferation involved in metanephros development
GO:72308; negative regulation of metanephric nephron tubule epithelial cell differentiation
GO:7584; response to nutrient
GO:8284; positive regulation of cell population proliferation
GO:9410; response to xenobiotic stimulus
GO:9612; response to mechanical stimulus
GO:14070; response to organic cyclic compound
GO:32869; cellular response to insulin stimulus
GO:42542; response to hydrogen peroxide
GO:51770; positive regulation of nitric-oxide synthase biosynthetic process
GO:71345; cellular response to cytokine stimulus
GO:71407; cellular response to organic cyclic compound

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:32991; protein-containing complex
GO:30425; dendrite
GO:30424; axon
GO:48471; perinuclear region of cytoplasm
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:70721; ISGF3 complex

Function:

GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5164; tumor necrosis factor receptor binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:45296; cadherin binding
GO:3690; double-stranded DNA binding
GO:42393; histone binding
GO:44389; ubiquitin-like protein ligase binding
GO:1222; transcription corepressor binding
GO:16922; nuclear receptor binding
GO:1990841; promoter-specific chromatin binding
GO:1223; transcription coactivator binding
GO:979; RNA polymerase II core promoter sequence-specific DNA binding
GO:35035; histone acetyltransferase binding
GO:31730; CCR5 chemokine receptor binding
GO:43565; sequence-specific DNA binding
GO:51721; protein phosphatase 2A binding

Hide GO terms

Caenorhabditis elegans

Danio rerio

Mus musculus

Rattus norvegicus

CellAge gene expression