The STAT3 gene and its putative association with human ageing

Cell Types

Fibroblast

Cell Lines

TIG-3

Cancer Cell?

No

Method

Overexpression

Type of senescence

Oncogene-induced

Senescence Effect

Induces

Primary Reference

Kojima et al. (2012) The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts. Cell Cycle 11(4)730-9 (PubMed)

HGNC symbol

STAT3

Aliases

APRF

Common name

signal transducer and activator of transcription 3

Entrez Id

6774

Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020].

Gene Ontology

Process:

GO:10628; positive regulation of gene expression
GO:16310; phosphorylation
GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:45893; positive regulation of transcription, DNA-templated
GO:6954; inflammatory response
GO:19221; cytokine-mediated signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:51726; regulation of cell cycle
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6952; defense response
GO:6606; protein import into nucleus
GO:42127; regulation of cell population proliferation
GO:7399; nervous system development
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:32755; positive regulation of interleukin-6 production
GO:32757; positive regulation of interleukin-8 production
GO:32760; positive regulation of tumor necrosis factor production
GO:1900017; positive regulation of cytokine production involved in inflammatory response
GO:60259; regulation of feeding behavior
GO:45747; positive regulation of Notch signaling pathway
GO:97009; energy homeostasis
GO:30335; positive regulation of cell migration
GO:7259; receptor signaling pathway via JAK-STAT
GO:32355; response to estradiol
GO:32870; cellular response to hormone stimulus
GO:60396; growth hormone receptor signaling pathway
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:60019; radial glial cell differentiation
GO:42593; glucose homeostasis
GO:32731; positive regulation of interleukin-1 beta production
GO:70102; interleukin-6-mediated signaling pathway
GO:10507; negative regulation of autophagy
GO:60397; growth hormone receptor signaling pathway via JAK-STAT
GO:1659; temperature homeostasis
GO:45648; positive regulation of erythrocyte differentiation
GO:43434; response to peptide hormone
GO:32733; positive regulation of interleukin-10 production
GO:2000635; negative regulation of primary miRNA processing
GO:72540; T-helper 17 cell lineage commitment
GO:42755; eating behavior
GO:19953; sexual reproduction
GO:30522; intracellular receptor signaling pathway
GO:44321; response to leptin
GO:33210; leptin-mediated signaling pathway
GO:72538; T-helper 17 type immune response
GO:1754; eye photoreceptor cell differentiation
GO:6366; transcription by RNA polymerase II
GO:7179; transforming growth factor beta receptor signaling pathway
GO:8283; cell population proliferation
GO:8285; negative regulation of cell population proliferation
GO:19827; stem cell population maintenance
GO:40014; regulation of multicellular organism growth
GO:42789; mRNA transcription by RNA polymerase II
GO:44320; cellular response to leptin stimulus
GO:45766; positive regulation of angiogenesis
GO:45820; negative regulation of glycolytic process
GO:48708; astrocyte differentiation
GO:1904685; positive regulation of metalloendopeptidase activity
GO:1905564; positive regulation of vascular endothelial cell proliferation
GO:1905618; positive regulation of miRNA mediated inhibition of translation
GO:2000637; positive regulation of gene silencing by miRNA
GO:2000737; negative regulation of stem cell differentiation
GO:2001223; negative regulation of neuron migration
GO:71310; cellular response to organic substance

Cellular component:

GO:5737; cytoplasm
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:5667; transcription regulator complex

Function:

GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:31490; chromatin DNA binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:46983; protein dimerization activity
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:19901; protein kinase binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:19903; protein phosphatase binding
GO:5102; signaling receptor binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:976; transcription cis-regulatory region binding
GO:4879; nuclear receptor activity
GO:35591; signaling adaptor activity
GO:43565; sequence-specific DNA binding
GO:70878; primary miRNA binding

Hide GO terms

Danio rerio

stat3

Mus musculus

Stat3

Rattus norvegicus

Stat3

GenAge human genes