Cell Senescence Entries for STK4

Cell Types
Fetal lung fibroblast, Umbilical cord fibroblast
Cell Lines
HUC-F2, TIG-1
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Udono et al. (2016) Impaired ATP6V0A2 expression contributes to Golgi dispersion and glycosylation changes in senescent cells. Sci Rep 5(2)17342 (PubMed)

STK4 Gene Information

HGNC symbol
STK4 
Aliases
KRS2; MST1; YSK3 
Common name
serine/threonine kinase 4 
Entrez Id
6789
Description
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008].

STK4 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:7165; signal transduction
GO:43065; positive regulation of apoptotic process
GO:18105; peptidyl-serine phosphorylation
GO:51262; protein tetramerization
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:35556; intracellular signal transduction
GO:35329; hippo signaling
GO:6606; protein import into nucleus
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:43408; regulation of MAPK cascade
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:1934; positive regulation of protein phosphorylation
GO:32092; positive regulation of protein binding
GO:46777; protein autophosphorylation
GO:902; cell morphogenesis
GO:50821; protein stabilization
GO:1569; branching involved in blood vessel morphogenesis
GO:1841; neural tube formation
GO:3157; endocardium development
GO:7417; central nervous system development
GO:8285; negative regulation of cell population proliferation
GO:30216; keratinocyte differentiation
GO:45600; positive regulation of fat cell differentiation
GO:46621; negative regulation of organ growth
GO:60215; primitive hemopoiesis
GO:60706; cell differentiation involved in embryonic placenta development
GO:60800; regulation of cell differentiation involved in embryonic placenta development
GO:97284; hepatocyte apoptotic process
GO:1902043; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1904237; positive regulation of substrate-dependent cell migration, cell attachment to substrate
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:16604; nuclear body
GO:32991; protein-containing complex
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:287; magnesium ion binding
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:43539; protein serine/threonine kinase activator activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
Hide GO terms

Homologs of STK4 in Model Organisms

Caenorhabditis elegans
cst-2
Drosophila melanogaster
hpo
Mus musculus
Stk4
Rattus norvegicus
Stk4

External links

OMIM
604965
Ensembl
ENSG00000101109
Entrez Gene
6789
UniGene
472838
1000 Genomes
1000 Genomes
HPRD
GenAtlas
STK4
GeneCards
STK4