Cell Senescence Entries for STN1

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Huang et al. (2013) Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in. Cell Res 22(12)1681-95 (PubMed)

STN1 Gene Information

HGNC symbol
STN1 
Aliases
bA541N10.2; FLJ22559; OBFC1 
Common name
STN1 subunit of CST complex 
Entrez Id
79991
Description
OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009].

STN1 Ontologies

Gene Ontology
Process: GO:723; telomere maintenance
GO:10833; telomere maintenance via telomere lengthening
GO:16233; telomere capping
GO:45740; positive regulation of DNA replication
GO:32211; negative regulation of telomere maintenance via telomerase
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:1650; fibrillar center
GO:5694; chromosome
GO:45111; intermediate filament cytoskeleton
GO:1990879; CST complex
Function: GO:5515; protein binding
GO:3676; nucleic acid binding
GO:3677; DNA binding
GO:43047; single-stranded telomeric DNA binding
GO:3697; single-stranded DNA binding
GO:42162; telomeric DNA binding
Hide GO terms

Homologs of STN1 in Model Organisms

Danio rerio
obfc1
Mus musculus
Obfc1
Rattus norvegicus
Obfc1

External links

OMIM
613128
Ensembl
ENSG00000107960
Entrez Gene
79991
UniGene
62314
1000 Genomes
1000 Genomes
HPRD
GenAtlas
STN1
GeneCards
STN1