Cell Senescence Entries for STUB1

Cell Types
Lung cancer
Cell Lines
A549, H1299, H460
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Biswas et al. (2018) The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance. Mol Cancer Res 15(6)651-659 (PubMed)

STUB1 Gene Information

HGNC symbol
STUB1 
Aliases
CHIP; HSPABP2; NY-CO-7; SDCCAG7; UBOX1 
Common name
STIP1 homology and U-box containing protein 1 
Entrez Id
10273
Description
This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014].

STUB1 Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:51865; protein autoubiquitination
GO:6511; ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:30433; ubiquitin-dependent ERAD pathway
GO:70534; protein K63-linked ubiquitination
GO:31647; regulation of protein stability
GO:31398; positive regulation of protein ubiquitination
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:2931; response to ischemia
GO:38128; ERBB2 signaling pathway
GO:6515; protein quality control for misfolded or incompletely synthesized proteins
GO:71456; cellular response to hypoxia
GO:71218; cellular response to misfolded protein
GO:30579; ubiquitin-dependent SMAD protein catabolic process
GO:31943; regulation of glucocorticoid metabolic process
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:34605; cellular response to heat
GO:45862; positive regulation of proteolysis
GO:51604; protein maturation
GO:90035; positive regulation of chaperone-mediated protein complex assembly
GO:30968; endoplasmic reticulum unfolded protein response
GO:32091; negative regulation of protein binding
GO:51443; positive regulation of ubiquitin-protein transferase activity
GO:61684; chaperone-mediated autophagy
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5783; endoplasmic reticulum
GO:30018; Z disc
GO:151; ubiquitin ligase complex
GO:101031; chaperone complex
GO:31371; ubiquitin conjugating enzyme complex
GO:42405; nuclear inclusion body
Function: GO:5515; protein binding
GO:16740; transferase activity
GO:4842; ubiquitin-protein transferase activity
GO:42803; protein homodimerization activity
GO:61630; ubiquitin protein ligase activity
GO:19899; enzyme binding
GO:51087; chaperone binding
GO:30544; Hsp70 protein binding
GO:46332; SMAD binding
GO:51879; Hsp90 protein binding
GO:48156; tau protein binding
GO:31625; ubiquitin protein ligase binding
GO:1664; G protein-coupled receptor binding
GO:19900; kinase binding
GO:34450; ubiquitin-ubiquitin ligase activity
GO:51787; misfolded protein binding
GO:30674; protein-macromolecule adaptor activity
GO:30911; TPR domain binding
GO:31072; heat shock protein binding
Hide GO terms

Homologs of STUB1 in Model Organisms

Caenorhabditis elegans
chn-1
Danio rerio
stub1
Drosophila melanogaster
CHIP
Mus musculus
Stub1
Rattus norvegicus
Stub1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Stub1
  • A homolog of this gene for Caenorhabditis elegans is present as chn-1
GenAge human genes
  • This gene is present as STUB1

External links

OMIM
607207
Ensembl
ENSG00000103266
Entrez Gene
10273
UniGene
592081
1000 Genomes
1000 Genomes
HPRD
GenAtlas
STUB1
GeneCards
STUB1