Cell Senescence Entries for SUMO2
- Cell Types
- Embryonic kidney
- Cell Lines
- HEK293
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Li et al. (2007) Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways. J Biol Chem 281(47)36221-7 (PubMed)
SUMO2 Gene Information
- HGNC symbol
- SUMO2
- Aliases
- SMT3B; SMT3H2
- Common name
- small ubiquitin like modifier 2
- Entrez Id
- 6613
- Description
- This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
SUMO2 Ontologies
- Gene Ontology
-
Process: GO:16925; protein sumoylation
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular component: GO:5634; nucleus
GO:16605; PML body
GO:5654; nucleoplasm
Hide GO termsFunction: GO:3723; RNA binding
GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
GO:31386; protein tag
GO:44389; ubiquitin-like protein ligase binding
Homologs of SUMO2 in Model Organisms
External links
- OMIM
- 603042
- Ensembl
- ENSG00000188612
- Entrez Gene
- 6613
- UniGene
- 546298
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SUMO2
- GeneCards
- SUMO2