The SUMO3 gene and its putative association with human ageing

Cell Senescence Entries for SUMO3

Cell Types: Embryonic kidney
Cell Lines: HEK294
Cancer Cell?: No
Method: Overexpression
Type of senescence: Unclear
Senescence Effect: Induces
Primary Reference: Li et al. (2007) Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways. J Biol Chem 281(47)36221-7 (PubMed)

HGNC symbol: SUMO3
Aliases: SMT3A; SMT3H1
Common name: small ubiquitin like modifier 3
Entrez Id: 6612
Description: This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014].

Gene Ontology

Process:

GO:16925; protein sumoylation
GO:43392; negative regulation of DNA binding
GO:1900180; regulation of protein localization to nucleus

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:16605; PML body
GO:5654; nucleoplasm
GO:776; kinetochore

Function:

GO:5515; protein binding
GO:31386; protein tag
GO:44389; ubiquitin-like protein ligase binding

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