The SYK gene and its putative association with human ageing

Cell Types

Melanoma

Cell Lines

501-mel, A375, SK-MEL-28

Cancer Cell?

Yes

Method

Overexpression

Type of senescence

Unclear

Senescence Effect

Induces

Primary Reference

Bailet et al. (2009) Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest. Cancer Res 69(7)2748-56 (PubMed)

HGNC symbol

SYK

Aliases

Common name

spleen associated tyrosine kinase

Entrez Id

6850

Description

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

Gene Ontology

Process:

GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:35556; intracellular signal transduction
GO:2376; immune system process
GO:45087; innate immune response
GO:1775; cell activation
GO:1819; positive regulation of cytokine production
GO:1820; serotonin secretion
GO:1945; lymph vessel development
GO:2092; positive regulation of receptor internalization
GO:2223; stimulatory C-type lectin receptor signaling pathway
GO:2281; macrophage activation involved in immune response
GO:2283; neutrophil activation involved in immune response
GO:2366; leukocyte activation involved in immune response
GO:2554; serotonin secretion by platelet
GO:2696; positive regulation of leukocyte activation
GO:7166; cell surface receptor signaling pathway
GO:7167; enzyme linked receptor protein signaling pathway
GO:7229; integrin-mediated signaling pathway
GO:10543; regulation of platelet activation
GO:18105; peptidyl-serine phosphorylation
GO:18108; peptidyl-tyrosine phosphorylation
GO:19370; leukotriene biosynthetic process
GO:31623; receptor internalization
GO:32481; positive regulation of type I interferon production
GO:32725; positive regulation of granulocyte macrophage colony-stimulating factor production
GO:32752; positive regulation of interleukin-3 production
GO:32753; positive regulation of interleukin-4 production
GO:32928; regulation of superoxide anion generation
GO:33630; positive regulation of cell adhesion mediated by integrin
GO:38063; collagen-activated tyrosine kinase receptor signaling pathway
GO:38156; interleukin-3-mediated signaling pathway
GO:42742; defense response to bacterium
GO:43306; positive regulation of mast cell degranulation
GO:43313; regulation of neutrophil degranulation
GO:43366; beta selection
GO:43410; positive regulation of MAPK cascade
GO:43507; positive regulation of JUN kinase activity
GO:45579; positive regulation of B cell differentiation
GO:45588; positive regulation of gamma-delta T cell differentiation
GO:45780; positive regulation of bone resorption
GO:46638; positive regulation of alpha-beta T cell differentiation
GO:46641; positive regulation of alpha-beta T cell proliferation
GO:46777; protein autophosphorylation
GO:48514; blood vessel morphogenesis
GO:50731; positive regulation of peptidyl-tyrosine phosphorylation
GO:50764; regulation of phagocytosis
GO:50778; positive regulation of immune response
GO:50850; positive regulation of calcium-mediated signaling
GO:50853; B cell receptor signaling pathway
GO:70372; regulation of ERK1 and ERK2 cascade
GO:71226; cellular response to molecule of fungal origin
GO:71404; cellular response to low-density lipoprotein particle stimulus
GO:90237; regulation of arachidonic acid secretion
GO:90330; regulation of platelet aggregation
GO:120162; positive regulation of cold-induced thermogenesis
GO:1990858; cellular response to lectin
GO:2250; adaptive immune response
GO:1525; angiogenesis
GO:30593; neutrophil chemotaxis
GO:30154; cell differentiation
GO:32755; positive regulation of interleukin-6 production
GO:32757; positive regulation of interleukin-8 production
GO:32760; positive regulation of tumor necrosis factor production
GO:30168; platelet activation
GO:9887; animal organ morphogenesis
GO:38095; Fc-epsilon receptor signaling pathway
GO:38096; Fc-gamma receptor signaling pathway involved in phagocytosis
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:32930; positive regulation of superoxide anion generation
GO:6606; protein import into nucleus
GO:43280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:71639; positive regulation of monocyte chemotactic protein-1 production
GO:31334; positive regulation of protein-containing complex assembly
GO:7159; leukocyte cell-cell adhesion
GO:32733; positive regulation of interleukin-10 production
GO:2862; negative regulation of inflammatory response to antigenic stimulus
GO:32735; positive regulation of interleukin-12 production
GO:71396; cellular response to lipid
GO:51090; regulation of DNA-binding transcription factor activity
GO:10803; regulation of tumor necrosis factor-mediated signaling pathway
GO:51712; positive regulation of killing of cells of other organism

Cellular component:

GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5829; cytosol
GO:19815; B cell receptor complex
GO:32009; early phagosome
GO:32991; protein-containing complex
GO:31234; extrinsic component of cytoplasmic side of plasma membrane
GO:5634; nucleus
GO:42101; T cell receptor complex

Function:

GO:5515; protein binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4715; non-membrane spanning protein tyrosine kinase activity
GO:19901; protein kinase binding
GO:19902; phosphatase binding
GO:35325; Toll-like receptor binding
GO:42169; SH2 domain binding
GO:5102; signaling receptor binding
GO:1784; phosphotyrosine residue binding
GO:5178; integrin binding
GO:4674; protein serine/threonine kinase activity
GO:43274; phospholipase binding
GO:97110; scaffold protein binding
GO:16170; interleukin-15 receptor binding

Hide GO terms

Danio rerio

syk

Drosophila melanogaster

shark

Mus musculus

Syk

Rattus norvegicus

Syk

LongevityMap