Cell Senescence Entries for SYT1

Cell Types
Lung cancer
Cell Lines
A549, H23
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Fei et al. (2020) Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells. Biosci Rep 39(2)117-26 (PubMed)

SYT1 Gene Information

HGNC symbol
SYT1 
Aliases
P65; SVP65; SYT 
Common name
synaptotagmin 1 
Entrez Id
6857
Description
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010].

SYT1 Ontologies

Gene Ontology
Process: GO:30154; cell differentiation
GO:7269; neurotransmitter secretion
GO:16192; vesicle-mediated transport
GO:7268; chemical synaptic transmission
GO:14059; regulation of dopamine secretion
GO:17156; calcium-ion regulated exocytosis
GO:17158; regulation of calcium ion-dependent exocytosis
GO:48488; synaptic vesicle endocytosis
GO:48791; calcium ion-regulated exocytosis of neurotransmitter
GO:71277; cellular response to calcium ion
GO:1903861; positive regulation of dendrite extension
GO:17157; regulation of exocytosis
GO:5513; detection of calcium ion
GO:50806; positive regulation of synaptic transmission
GO:51966; regulation of synaptic transmission, glutamatergic
GO:98746; fast, calcium ion-dependent exocytosis of neurotransmitter
GO:1903235; positive regulation of calcium ion-dependent exocytosis of neurotransmitter
GO:1903305; regulation of regulated secretory pathway
GO:7420; brain development
GO:16079; synaptic vesicle exocytosis
GO:31340; positive regulation of vesicle fusion
GO:33603; positive regulation of dopamine secretion
GO:45956; positive regulation of calcium ion-dependent exocytosis
GO:48278; vesicle docking
GO:51291; protein heterooligomerization
GO:51592; response to calcium ion
GO:61669; spontaneous neurotransmitter secretion
GO:71911; synchronous neurotransmitter secretion
GO:99502; calcium-dependent activation of synaptic vesicle fusion
GO:2000300; regulation of synaptic vesicle exocytosis
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:31410; cytoplasmic vesicle
GO:30054; cell junction
GO:8021; synaptic vesicle
GO:45202; synapse
GO:30672; synaptic vesicle membrane
GO:42584; chromaffin granule membrane
GO:5886; plasma membrane
GO:30658; transport vesicle membrane
GO:30424; axon
GO:31045; dense core granule
GO:70382; exocytic vesicle
GO:43005; neuron projection
GO:30669; clathrin-coated endocytic vesicle membrane
GO:61202; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:60201; clathrin-sculpted acetylcholine transport vesicle membrane
GO:60203; clathrin-sculpted glutamate transport vesicle membrane
GO:70083; clathrin-sculpted monoamine transport vesicle membrane
GO:5794; Golgi apparatus
GO:30141; secretory granule
GO:30285; integral component of synaptic vesicle membrane
GO:42734; presynaptic membrane
GO:43229; intracellular organelle
GO:44306; neuron projection terminus
GO:60076; excitatory synapse
GO:98686; hippocampal mossy fiber to CA3 synapse
GO:98978; glutamatergic synapse
Function: GO:46872; metal ion binding
GO:5509; calcium ion binding
GO:5515; protein binding
GO:5544; calcium-dependent phospholipid binding
GO:149; SNARE binding
GO:19905; syntaxin binding
GO:1786; phosphatidylserine binding
GO:30276; clathrin binding
GO:50750; low-density lipoprotein particle receptor binding
GO:17075; syntaxin-1 binding
GO:5516; calmodulin binding
GO:5543; phospholipid binding
GO:5546; phosphatidylinositol-4,5-bisphosphate binding
GO:8022; protein C-terminus binding
GO:30348; syntaxin-3 binding
GO:42802; identical protein binding
GO:46982; protein heterodimerization activity
GO:48306; calcium-dependent protein binding
GO:61891; calcium ion sensor activity
Hide GO terms

Homologs of SYT1 in Model Organisms

Danio rerio
syt1a
Mus musculus
Syt1
Rattus norvegicus
Syt1

In other databases

CellAge gene expression
  • This gene is present as SYT1

External links

OMIM
185605
Ensembl
ENSG00000067715
Entrez Gene
6857
UniGene
310545
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SYT1
GeneCards
SYT1