Cell Senescence Entries for SYT7

Cell Types
Lung cancer
Cell Lines
A549, H23
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Fei et al. (2020) Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells. Biosci Rep 39(2)117-26 (PubMed)

SYT7 Gene Information

HGNC symbol
SYT7 
Aliases
IPCA-7; MGC150517; PCANAP7; SYT-VII 
Common name
synaptotagmin 7 
Entrez Id
9066
Description
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011].

SYT7 Ontologies

Gene Ontology
Process: GO:6887; exocytosis
GO:16192; vesicle-mediated transport
GO:6909; phagocytosis
GO:50796; regulation of insulin secretion
GO:14059; regulation of dopamine secretion
GO:17156; calcium-ion regulated exocytosis
GO:17158; regulation of calcium ion-dependent exocytosis
GO:71277; cellular response to calcium ion
GO:1778; plasma membrane repair
GO:36465; synaptic vesicle recycling
GO:46850; regulation of bone remodeling
GO:48791; calcium ion-regulated exocytosis of neurotransmitter
GO:50764; regulation of phagocytosis
GO:70092; regulation of glucagon secretion
GO:90119; vesicle-mediated cholesterol transport
GO:90385; phagosome-lysosome fusion
GO:1990926; short-term synaptic potentiation
GO:1990927; calcium ion regulated lysosome exocytosis
GO:45956; positive regulation of calcium ion-dependent exocytosis
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:31410; cytoplasmic vesicle
GO:5886; plasma membrane
GO:5765; lysosomal membrane
GO:30054; cell junction
GO:42995; cell projection
GO:5777; peroxisome
GO:5764; lysosome
GO:45202; synapse
GO:5829; cytosol
GO:30670; phagocytic vesicle membrane
GO:8021; synaptic vesicle
GO:5778; peroxisomal membrane
GO:30672; synaptic vesicle membrane
GO:42734; presynaptic membrane
GO:30658; transport vesicle membrane
GO:70062; extracellular exosome
GO:70382; exocytic vesicle
GO:32009; early phagosome
GO:31045; dense core granule
GO:98686; hippocampal mossy fiber to CA3 synapse
GO:99056; integral component of presynaptic membrane
Function: GO:46872; metal ion binding
GO:5515; protein binding
GO:5544; calcium-dependent phospholipid binding
GO:5516; calmodulin binding
GO:5509; calcium ion binding
GO:149; SNARE binding
GO:5546; phosphatidylinositol-4,5-bisphosphate binding
GO:1786; phosphatidylserine binding
GO:30276; clathrin binding
GO:19905; syntaxin binding
Hide GO terms

Homologs of SYT7 in Model Organisms

Danio rerio
uncharacterized_E7F5
Drosophila melanogaster
Syt7
Mus musculus
Syt7
Rattus norvegicus
Syt7

External links

OMIM
604146
Ensembl
ENSG00000011347
Entrez Gene
9066
UniGene
684589
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SYT7
GeneCards
SYT7