Cell Senescence Entries for TACC3

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Schmidt et al. (2011) The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene 29(46)6184-92 (PubMed)

TACC3 Gene Information

HGNC symbol
TACC3 
Aliases
ERIC-1; ERIC1; maskin; Tacc4 
Common name
transforming acidic coiled-coil containing protein 3 
Entrez Id
10460
Description
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011].

TACC3 Ontologies

Gene Ontology
Process: GO:7052; mitotic spindle organization
GO:7049; cell cycle
GO:51301; cell division
GO:226; microtubule cytoskeleton organization
GO:8283; cell population proliferation
GO:21987; cerebral cortex development
GO:60236; regulation of mitotic spindle organization
GO:1902850; microtubule cytoskeleton organization involved in mitosis
GO:7091; metaphase/anaphase transition of mitotic cell cycle
Cellular component: GO:43231; intracellular membrane-bounded organelle
GO:5829; cytosol
GO:72686; mitotic spindle
GO:34451; centriolar satellite
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5815; microtubule organizing center
GO:5819; spindle
GO:922; spindle pole
Function: GO:5515; protein binding
Hide GO terms

Homologs of TACC3 in Model Organisms

Danio rerio
tacc3
Mus musculus
Tacc3

In other databases

CellAge gene expression
  • This gene is present as TACC3

External links

OMIM
605303
Ensembl
ENSG00000013810
Entrez Gene
10460
UniGene
104019
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TACC3
GeneCards
TACC3