Cell Senescence Entries for TBK1

Cell Types
Breast cancer
Cell Lines
HCC1954, SKBR3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Deng et al. (2014) shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer. Cancer Res 74(7)2119-30 (PubMed)

TBK1 Gene Information

HGNC symbol
TBK1 
Aliases
NAK 
Common name
TANK binding kinase 1 
Entrez Id
29110
Description
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021].

TBK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:18105; peptidyl-serine phosphorylation
GO:6954; inflammatory response
GO:32479; regulation of type I interferon production
GO:9615; response to virus
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:32727; positive regulation of interferon-alpha production
GO:32728; positive regulation of interferon-beta production
GO:18107; peptidyl-threonine phosphorylation
GO:7249; I-kappaB kinase/NF-kappaB signaling
GO:1901214; regulation of neuron death
GO:32481; positive regulation of type I interferon production
GO:16239; positive regulation of macroautophagy
GO:60337; type I interferon signaling pathway
GO:2218; activation of innate immune response
GO:10468; regulation of gene expression
GO:10629; negative regulation of gene expression
GO:44565; dendritic cell proliferation
GO:50830; defense response to Gram-positive bacterium
GO:60340; positive regulation of type I interferon-mediated signaling pathway
GO:1904417; positive regulation of xenophagy
Cellular component: GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:1902554; serine/threonine protein kinase complex
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:5524; ATP binding
GO:16740; transferase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:51219; phosphoprotein binding
GO:19903; protein phosphatase binding
GO:3676; nucleic acid binding
GO:42802; identical protein binding
Hide GO terms

Homologs of TBK1 in Model Organisms

Danio rerio
tbk1
Mus musculus
Tbk1
Rattus norvegicus
Tbk1

External links

OMIM
604834
Ensembl
ENSG00000183735
Entrez Gene
29110
UniGene
505874
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TBK1
GeneCards
TBK1