Cell Senescence Entries for TBX2

Cell Types
Melanoma
Cell Lines
B16
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Vance et al. (2005) Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas. Cancer Res 65(6)2260-8 (PubMed)

TBX2 Gene Information

HGNC symbol
TBX2 
Aliases
 
Common name
T-box transcription factor 2 
Entrez Id
6909
Description
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008].

TBX2 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:3007; heart morphogenesis
GO:3148; outflow tract septum morphogenesis
GO:3151; outflow tract morphogenesis
GO:3203; endocardial cushion morphogenesis
GO:3256; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:6915; apoptotic process
GO:7219; Notch signaling pathway
GO:7521; muscle cell fate determination
GO:7569; cell aging
GO:8543; fibroblast growth factor receptor signaling pathway
GO:22008; neurogenesis
GO:32526; response to retinoic acid
GO:35909; aorta morphogenesis
GO:36302; atrioventricular canal development
GO:42733; embryonic digit morphogenesis
GO:43474; pigment metabolic process involved in pigmentation
GO:45892; negative regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:48596; embryonic camera-type eye morphogenesis
GO:48738; cardiac muscle tissue development
GO:51145; smooth muscle cell differentiation
GO:60021; roof of mouth development
GO:60045; positive regulation of cardiac muscle cell proliferation
GO:60441; epithelial tube branching involved in lung morphogenesis
GO:60465; pharynx development
GO:60560; developmental growth involved in morphogenesis
GO:60596; mammary placode formation
GO:60916; mesenchymal cell proliferation involved in lung development
GO:72105; ureteric peristalsis
GO:90103; cochlea morphogenesis
GO:97325; melanocyte proliferation
GO:1901208; negative regulation of heart looping
GO:1901211; negative regulation of cardiac chamber formation
GO:1902808; positive regulation of cell cycle G1/S phase transition
GO:1905222; atrioventricular canal morphogenesis
GO:8284; positive regulation of cell population proliferation
GO:6357; regulation of transcription by RNA polymerase II
GO:1708; cell fate specification
GO:3272; endocardial cushion formation
GO:90398; cellular senescence
GO:1905072; cardiac jelly development
GO:1947; heart looping
GO:35050; embryonic heart tube development
GO:8016; regulation of heart contraction
GO:2000773; negative regulation of cellular senescence
Cellular component: GO:5634; nucleus
GO:5667; transcription regulator complex
GO:5737; cytoplasm
GO:785; chromatin
Function: GO:3677; DNA binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3700; DNA-binding transcription factor activity
GO:42826; histone deacetylase binding
GO:140297; DNA-binding transcription factor binding
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:1990837; sequence-specific double-stranded DNA binding
Hide GO terms

Homologs of TBX2 in Model Organisms

Danio rerio
tbx2a
Mus musculus
Tbx2

External links

OMIM
600747
Ensembl
ENSG00000121068
Entrez Gene
6909
UniGene
531085
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TBX2
GeneCards
TBX2