Cell Senescence Entries for TBX3

Cell Types
Foreskin fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Kumar P et al. (2015) Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife 3(2)117-26 (PubMed)

TBX3 Gene Information

HGNC symbol
TBX3 
Aliases
TBX3-ISO; UMS; XHL 
Common name
T-box transcription factor 3 
Entrez Id
6926
Description
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008].

TBX3 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:1568; blood vessel development
GO:1701; in utero embryonic development
GO:1947; heart looping
GO:3007; heart morphogenesis
GO:3151; outflow tract morphogenesis
GO:3167; atrioventricular bundle cell differentiation
GO:7569; cell aging
GO:10159; specification of animal organ position
GO:19827; stem cell population maintenance
GO:21761; limbic system development
GO:30857; negative regulation of epithelial cell differentiation
GO:30879; mammary gland development
GO:35050; embryonic heart tube development
GO:35108; limb morphogenesis
GO:35116; embryonic hindlimb morphogenesis
GO:36302; atrioventricular canal development
GO:42127; regulation of cell population proliferation
GO:42472; inner ear morphogenesis
GO:42733; embryonic digit morphogenesis
GO:45893; positive regulation of transcription, DNA-templated
GO:48752; semicircular canal morphogenesis
GO:51145; smooth muscle cell differentiation
GO:55007; cardiac muscle cell differentiation
GO:60021; roof of mouth development
GO:60412; ventricular septum morphogenesis
GO:60444; branching involved in mammary gland duct morphogenesis
GO:60596; mammary placode formation
GO:60923; cardiac muscle cell fate commitment
GO:60931; sinoatrial node cell development
GO:72105; ureteric peristalsis
GO:1905222; atrioventricular canal morphogenesis
GO:2000648; positive regulation of stem cell proliferation
GO:6357; regulation of transcription by RNA polymerase II
GO:8284; positive regulation of cell population proliferation
GO:1501; skeletal system development
GO:7417; central nervous system development
GO:1708; cell fate specification
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45662; negative regulation of myoblast differentiation
GO:9887; animal organ morphogenesis
GO:35136; forelimb morphogenesis
GO:3205; cardiac chamber development
GO:3272; endocardial cushion formation
GO:8595; anterior/posterior axis specification, embryo
GO:30539; male genitalia development
GO:30540; female genitalia development
GO:32275; luteinizing hormone secretion
GO:35115; embryonic forelimb morphogenesis
GO:45787; positive regulation of cell cycle
GO:46884; follicle-stimulating hormone secretion
GO:48332; mesoderm morphogenesis
GO:60317; cardiac epithelial to mesenchymal transition
GO:90398; cellular senescence
GO:1905072; cardiac jelly development
GO:2000137; negative regulation of cell proliferation involved in heart morphogenesis
Cellular component: GO:5634; nucleus
GO:785; chromatin
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
Hide GO terms

Homologs of TBX3 in Model Organisms

Danio rerio
tbx3a
Drosophila melanogaster
bi
Mus musculus
Tbx3
Rattus norvegicus
Tbx3

External links

OMIM
601621
Ensembl
ENSG00000135111
Entrez Gene
6926
UniGene
744016
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TBX3
GeneCards
TBX3