The TERT gene and its putative association with human ageing

Cell Senescence Entries for TERT

Cell Types: Foreskin fibroblast, Retinal pigment epithelial
Cell Lines: BJ, RPE-340
Cancer Cell?: No
Method: Overexpression
Type of senescence: Replicative
Senescence Effect: Inhibits
Primary Reference: Bodnar et al. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279(5349)349-52 (PubMed)

TERT Gene Information

HGNC symbol: TERT
Aliases: EST2; hEST2; TCS1; TP2; TRT
Common name: telomerase reverse transcriptase
Entrez Id: 7015
Description: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008].

TERT Ontologies

Gene Ontology

Process:

GO:7004; telomere maintenance via telomerase
GO:71456; cellular response to hypoxia
GO:71897; DNA biosynthetic process
GO:2000773; negative regulation of cellular senescence
GO:723; telomere maintenance
GO:1172; transcription, RNA-templated
GO:6278; RNA-dependent DNA biosynthetic process
GO:7005; mitochondrion organization
GO:10629; negative regulation of gene expression
GO:22616; DNA strand elongation
GO:30177; positive regulation of Wnt signaling pathway
GO:30422; production of siRNA involved in RNA interference
GO:31647; regulation of protein stability
GO:32092; positive regulation of protein binding
GO:42635; positive regulation of hair cycle
GO:43066; negative regulation of apoptotic process
GO:43524; negative regulation of neuron apoptotic process
GO:45766; positive regulation of angiogenesis
GO:46326; positive regulation of glucose import
GO:46686; response to cadmium ion
GO:51000; positive regulation of nitric-oxide synthase activity
GO:62103; double-stranded RNA biosynthetic process
GO:70200; establishment of protein localization to telomere
GO:90399; replicative senescence
GO:1900087; positive regulation of G1/S transition of mitotic cell cycle
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903620; positive regulation of transdifferentiation
GO:1903704; negative regulation of production of siRNA involved in RNA interference
GO:1903799; negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1904707; positive regulation of vascular associated smooth muscle cell proliferation
GO:1904751; positive regulation of protein localization to nucleolus
GO:1904754; positive regulation of vascular associated smooth muscle cell migration
GO:2000352; negative regulation of endothelial cell apoptotic process
GO:2000648; positive regulation of stem cell proliferation
GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular component:

GO:781; chromosome, telomeric region
GO:333; telomerase catalytic core complex
GO:5697; telomerase holoenzyme complex
GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5694; chromosome
GO:5730; nucleolus
GO:16605; PML body
GO:42645; mitochondrial nucleoid
GO:1990572; TERT-RMRP complex
GO:783; nuclear telomere cap complex
GO:5739; mitochondrion
GO:5886; plasma membrane
GO:31379; RNA-directed RNA polymerase complex

Function:

GO:5515; protein binding
GO:3720; telomerase activity
GO:3721; telomerase RNA reverse transcriptase activity
GO:3964; RNA-directed DNA polymerase activity
GO:46872; metal ion binding
GO:16740; transferase activity
GO:3677; DNA binding
GO:16779; nucleotidyltransferase activity
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:49; tRNA binding
GO:1223; transcription coactivator binding
GO:3723; RNA binding
GO:3968; RNA-directed 5'-3' RNA polymerase activity
GO:8022; protein C-terminus binding
GO:42162; telomeric DNA binding
GO:47485; protein N-terminus binding
GO:51087; chaperone binding
GO:70034; telomerase RNA binding
GO:98680; template-free RNA nucleotidyltransferase

Hide GO terms

Homologs of TERT in Model Organisms

Danio rerio: tert
Mus musculus: Tert
Rattus norvegicus: Tert
Saccharomyces cerevisiae: EST2
Schizosaccharomyces pombe: trt1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Tert

GenAge human genes

This gene is present as TERT

LongevityMap

This gene is present as TERT

Cell Senescence Entries for TERT

TERT Gene Information

TERT Ontologies

Homologs of TERT in Model Organisms

In other databases

External links