The TGFB2 gene and its putative association with human ageing

Cell Types

Lung cancer

Cell Lines

A549

Cancer Cell?

Yes

Method

Knockdown, Mutation, Overexpression

Type of senescence

Oncogene-induced

Senescence Effect

Inhibits

Primary Reference

Gao et al. (2019) Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun 10(1)1665 (PubMed)

HGNC symbol

TGFB2

Aliases

Common name

transforming growth factor beta 2

Entrez Id

7042

Description

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].

Gene Ontology

Process:

GO:50778; positive regulation of immune response
GO:51781; positive regulation of cell division
GO:9410; response to xenobiotic stimulus
GO:8284; positive regulation of cell population proliferation
GO:48699; generation of neurons
GO:7507; heart development
GO:30593; neutrophil chemotaxis
GO:8285; negative regulation of cell population proliferation
GO:48666; neuron development
GO:1654; eye development
GO:30509; BMP signaling pathway
GO:60395; SMAD protein signal transduction
GO:7179; transforming growth factor beta receptor signaling pathway
GO:42127; regulation of cell population proliferation
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:10862; positive regulation of pathway-restricted SMAD protein phosphorylation
GO:31069; hair follicle morphogenesis
GO:9792; embryo development ending in birth or egg hatching
GO:30097; hemopoiesis
GO:8219; cell death
GO:30307; positive regulation of cell growth
GO:33630; positive regulation of cell adhesion mediated by integrin
GO:62009; secondary palate development
GO:1843; neural tube closure
GO:10629; negative regulation of gene expression
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:3148; outflow tract septum morphogenesis
GO:42060; wound healing
GO:16525; negative regulation of angiogenesis
GO:30199; collagen fibril organization
GO:60389; pathway-restricted SMAD protein phosphorylation
GO:60412; ventricular septum morphogenesis
GO:45787; positive regulation of cell cycle
GO:60317; cardiac epithelial to mesenchymal transition
GO:3181; atrioventricular valve morphogenesis
GO:3203; endocardial cushion morphogenesis
GO:32147; activation of protein kinase activity
GO:3007; heart morphogenesis
GO:97191; extrinsic apoptotic signaling pathway
GO:30308; negative regulation of cell growth
GO:16477; cell migration
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:43525; positive regulation of neuron apoptotic process
GO:3184; pulmonary valve morphogenesis
GO:1837; epithelial to mesenchymal transition
GO:1822; kidney development
GO:45747; positive regulation of Notch signaling pathway
GO:60038; cardiac muscle cell proliferation
GO:3407; neural retina development
GO:6468; protein phosphorylation
GO:9611; response to wounding
GO:48566; embryonic digestive tract development
GO:1501; skeletal system development
GO:50714; positive regulation of protein secretion
GO:60065; uterus development
GO:1942; hair follicle development
GO:1666; response to hypoxia
GO:42416; dopamine biosynthetic process
GO:32570; response to progesterone
GO:45823; positive regulation of heart contraction
GO:45726; positive regulation of integrin biosynthetic process
GO:7435; salivary gland morphogenesis
GO:10936; negative regulation of macrophage cytokine production
GO:42476; odontogenesis
GO:42704; uterine wall breakdown
GO:45216; cell-cell junction organization
GO:30326; embryonic limb morphogenesis
GO:902; cell morphogenesis
GO:3149; membranous septum morphogenesis
GO:61626; pharyngeal arch artery morphogenesis
GO:8347; glial cell migration
GO:8584; male gonad development
GO:3222; ventricular trabecula myocardium morphogenesis
GO:1905007; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:51795; positive regulation of timing of catagen
GO:3215; cardiac right ventricle morphogenesis
GO:3274; endocardial cushion fusion
GO:45778; positive regulation of ossification
GO:50680; negative regulation of epithelial cell proliferation
GO:3289; atrial septum primum morphogenesis
GO:60413; atrial septum morphogenesis
GO:48103; somatic stem cell division
GO:3179; heart valve morphogenesis
GO:10002; cardioblast differentiation
GO:10634; positive regulation of epithelial cell migration
GO:10693; negative regulation of alkaline phosphatase activity
GO:32874; positive regulation of stress-activated MAPK cascade
GO:32909; regulation of transforming growth factor beta2 production
GO:35910; ascending aorta morphogenesis
GO:46580; negative regulation of Ras protein signal transduction
GO:48839; inner ear development
GO:51794; regulation of timing of catagen
GO:51891; positive regulation of cardioblast differentiation
GO:1902256; regulation of apoptotic process involved in outflow tract morphogenesis
GO:1903701; substantia propria of cornea development
GO:1904888; cranial skeletal system development
GO:1905006; negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

Cellular component:

GO:5615; extracellular space
GO:5576; extracellular region
GO:30424; axon
GO:62023; collagen-containing extracellular matrix
GO:31093; platelet alpha granule lumen
GO:43025; neuronal cell body

Function:

GO:5515; protein binding
GO:8083; growth factor activity
GO:42803; protein homodimerization activity
GO:5102; signaling receptor binding
GO:5160; transforming growth factor beta receptor binding
GO:1540; amyloid-beta binding
GO:5114; type II transforming growth factor beta receptor binding
GO:34714; type III transforming growth factor beta receptor binding
GO:5125; cytokine activity

Hide GO terms

Danio rerio

tgfb2

Mus musculus

Tgfb2

Rattus norvegicus

Tgfb2

LongevityMap