Cell Senescence Entries for TGFBI
- Cell Types
- Lung cancer
- Cell Lines
- MDA-MB-231, NCI-H28
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Primary Reference
- Li et al. (2013) The role of TGFBI in mesothelioma and breast cancer: association with tumor suppression. BMC Cancer 12(2)239 (PubMed)
TGFBI Gene Information
- HGNC symbol
- TGFBI
- Aliases
- BIGH3; CDB1; CDGG1; CSD1; CSD2; CSD3; LCD1
- Common name
- transforming growth factor beta induced
- Entrez Id
- 7045
- Description
- This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008].
TGFBI Ontologies
- Gene Ontology
-
Process: GO:7155; cell adhesion
GO:50896; response to stimulus
GO:7601; visual perception
GO:1525; angiogenesis
GO:2062; chondrocyte differentiation
GO:8283; cell population proliferation
GO:30198; extracellular matrix organization
GO:7162; negative regulation of cell adhesion
Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:5886; plasma membrane
GO:5604; basement membrane
GO:31012; extracellular matrix
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:5802; trans-Golgi network
Hide GO termsFunction: GO:5515; protein binding
GO:5518; collagen binding
GO:50840; extracellular matrix binding
GO:42802; identical protein binding
GO:5178; integrin binding
GO:5201; extracellular matrix structural constituent
GO:50839; cell adhesion molecule binding
Homologs of TGFBI in Model Organisms
- Danio rerio
- tgfbi
- Mus musculus
- Tgfbi
- Rattus norvegicus
- Tgfbi
- Schizosaccharomyces pombe
- SPAC22H12.05c
External links
- OMIM
- 601692
- Ensembl
- ENSG00000120708
- Entrez Gene
- 7045
- UniGene
- 369397
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TGFBI
- GeneCards
- TGFBI