The TGFBR2 gene and its putative association with human ageing

Cell Types

Lung cancer, Lung fibroblast

Cell Lines

A549, IMR-90, MCF-7, SK-HEP-1

Cancer Cell?

Yes

Method

Knockdown, Overexpression

Type of senescence

Unclear

Senescence Effect

Unclear

Primary Reference

Rapisarda et al. (2017) Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway. Cell Rep 18(10)2480-2493 (PubMed)

Cell Types

Lung cancer, Lung fibroblast

Cell Lines

A549, IMR-90, MCF-7, SK-HEP-1

Cancer Cell?

Yes

Method

Knockdown, Overexpression

Type of senescence

Unclear

Senescence Effect

Unclear

Primary Reference

Gao et al. (2019) Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun 10(1)1665 (PubMed)

HGNC symbol

TGFBR2

Aliases

MFS2; TBR-ii; TBRII

Common name

transforming growth factor beta receptor 2

Entrez Id

7048

Description

The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017].

Gene Ontology

Process:

GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:30154; cell differentiation
GO:40008; regulation of growth
GO:7178; transmembrane receptor protein serine/threonine kinase signaling pathway
GO:51239; regulation of multicellular organismal process
GO:1569; branching involved in blood vessel morphogenesis
GO:1570; vasculogenesis
GO:1666; response to hypoxia
GO:1701; in utero embryonic development
GO:1947; heart looping
GO:2053; positive regulation of mesenchymal cell proliferation
GO:2088; lens development in camera-type eye
GO:2651; positive regulation of tolerance induction to self antigen
GO:2663; positive regulation of B cell tolerance induction
GO:2666; positive regulation of T cell tolerance induction
GO:3148; outflow tract septum morphogenesis
GO:3149; membranous septum morphogenesis
GO:3151; outflow tract morphogenesis
GO:3181; atrioventricular valve morphogenesis
GO:3186; tricuspid valve morphogenesis
GO:3214; cardiac left ventricle morphogenesis
GO:3274; endocardial cushion fusion
GO:3417; growth plate cartilage development
GO:3430; growth plate cartilage chondrocyte growth
GO:6898; receptor-mediated endocytosis
GO:7179; transforming growth factor beta receptor signaling pathway
GO:7182; common-partner SMAD protein phosphorylation
GO:7219; Notch signaling pathway
GO:7224; smoothened signaling pathway
GO:7369; gastrulation
GO:7420; brain development
GO:7507; heart development
GO:7566; embryo implantation
GO:7568; aging
GO:7584; response to nutrient
GO:8285; negative regulation of cell population proliferation
GO:9612; response to mechanical stimulus
GO:9749; response to glucose
GO:9887; animal organ morphogenesis
GO:10033; response to organic substance
GO:10468; regulation of gene expression
GO:10634; positive regulation of epithelial cell migration
GO:14070; response to organic cyclic compound
GO:30324; lung development
GO:31100; animal organ regeneration
GO:32147; activation of protein kinase activity
GO:35162; embryonic hemopoiesis
GO:42060; wound healing
GO:42127; regulation of cell population proliferation
GO:43011; myeloid dendritic cell differentiation
GO:43415; positive regulation of skeletal muscle tissue regeneration
GO:43627; response to estrogen
GO:45766; positive regulation of angiogenesis
GO:48545; response to steroid hormone
GO:48565; digestive tract development
GO:48661; positive regulation of smooth muscle cell proliferation
GO:48701; embryonic cranial skeleton morphogenesis
GO:51138; positive regulation of NK T cell differentiation
GO:51216; cartilage development
GO:60044; negative regulation of cardiac muscle cell proliferation
GO:60412; ventricular septum morphogenesis
GO:60425; lung morphogenesis
GO:60433; bronchus development
GO:60434; bronchus morphogenesis
GO:60439; trachea morphogenesis
GO:60440; trachea formation
GO:60443; mammary gland morphogenesis
GO:60463; lung lobe morphogenesis
GO:62009; secondary palate development
GO:70723; response to cholesterol
GO:1905007; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905317; inferior endocardial cushion morphogenesis
GO:1990086; lens fiber cell apoptotic process
GO:1990428; miRNA transport
GO:32924; activin receptor signaling pathway
GO:71363; cellular response to growth factor stimulus
GO:60389; pathway-restricted SMAD protein phosphorylation
GO:18105; peptidyl-serine phosphorylation
GO:18107; peptidyl-threonine phosphorylation
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:8284; positive regulation of cell population proliferation
GO:2000379; positive regulation of reactive oxygen species metabolic process
GO:9410; response to xenobiotic stimulus
GO:10862; positive regulation of pathway-restricted SMAD protein phosphorylation
GO:1568; blood vessel development
GO:2000563; positive regulation of CD4-positive, alpha-beta T cell proliferation

Cellular component:

GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:45121; membrane raft
GO:5829; cytosol
GO:5737; cytoplasm
GO:5887; integral component of plasma membrane
GO:5901; caveola
GO:9897; external side of plasma membrane
GO:9986; cell surface
GO:43235; receptor complex
GO:70021; transforming growth factor beta ligand-receptor complex

Function:

GO:5515; protein binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:38023; signaling receptor activity
GO:4675; transmembrane receptor protein serine/threonine kinase activity
GO:5024; transforming growth factor beta-activated receptor activity
GO:5026; transforming growth factor beta receptor activity, type II
GO:31435; mitogen-activated protein kinase kinase kinase binding
GO:46332; SMAD binding
GO:50431; transforming growth factor beta binding
GO:34713; type I transforming growth factor beta receptor binding
GO:48185; activin binding
GO:5539; glycosaminoglycan binding
GO:17002; activin-activated receptor activity
GO:34714; type III transforming growth factor beta receptor binding

Hide GO terms

Caenorhabditis elegans

Danio rerio

Mus musculus

Rattus norvegicus

GenAge model organism genes