Cell Senescence Entries for THRB

Cell Types
Breast cancer, Thyroid carcinoma
Cell Lines
ARO, MCF-7
Cancer Cell?
Yes
Method
Mutation, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Unclear
Primary Reference
Matsuse et al. (2008) A novel role for thyroid hormone receptor beta in cellular radiosensitivity. J Radiat Res 49(1)17-27 (PubMed)

THRB Gene Information

HGNC symbol
THRB 
Aliases
ERBA-BETA; ERBA2; GRTH; NR1A2; PRTH; THR1; THRB1; THRB2; TRbeta 
Common name
thyroid hormone receptor beta 
Entrez Id
7068
Description
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008].

THRB Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:30522; intracellular receptor signaling pathway
GO:122; negative regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:42789; mRNA transcription by RNA polymerase II
GO:9755; hormone-mediated signaling pathway
GO:6351; transcription, DNA-templated
GO:2154; thyroid hormone mediated signaling pathway
GO:2157; positive regulation of thyroid hormone mediated signaling pathway
GO:97067; cellular response to thyroid hormone stimulus
GO:6357; regulation of transcription by RNA polymerase II
GO:7605; sensory perception of sound
GO:7621; negative regulation of female receptivity
GO:8016; regulation of heart contraction
GO:8050; female courtship behavior
GO:9887; animal organ morphogenesis
GO:45892; negative regulation of transcription, DNA-templated
GO:46549; retinal cone cell development
GO:60509; type I pneumocyte differentiation
GO:97474; retinal cone cell apoptotic process
Cellular component: GO:5634; nucleus
GO:16604; nuclear body
GO:5654; nucleoplasm
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:4879; nuclear receptor activity
GO:19899; enzyme binding
GO:70324; thyroid hormone binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1990837; sequence-specific double-stranded DNA binding
GO:1223; transcription coactivator binding
GO:3682; chromatin binding
GO:31490; chromatin DNA binding
Hide GO terms

Homologs of THRB in Model Organisms

Caenorhabditis elegans
daf-12
Danio rerio
thrb
Mus musculus
Thrb
Rattus norvegicus
Thrb

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as daf-12

External links

OMIM
190160
Ensembl
ENSG00000151090
Entrez Gene
7068
UniGene
713754
1000 Genomes
1000 Genomes
HPRD
GenAtlas
THRB
GeneCards
THRB