Cell Senescence Entries for TIMELESS

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
2BS, HEK293T
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Shen et al. (2019) Loss of circadian protein TIMELESS accelerates the progression of cellular senescence. Biochem Biophys Res Commun 503(4)2784-2791 (PubMed)

TIMELESS Gene Information

HGNC symbol
TIMELESS 
Aliases
hTIM; TIM; TIM1 
Common name
timeless circadian regulator 
Entrez Id
8914
Description
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014].

TIMELESS Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:45892; negative regulation of transcription, DNA-templated
GO:51301; cell division
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:7623; circadian rhythm
GO:48511; rhythmic process
GO:1905168; positive regulation of double-strand break repair via homologous recombination
GO:2000781; positive regulation of double-strand break repair
GO:44770; cell cycle phase transition
GO:42752; regulation of circadian rhythm
GO:2009; morphogenesis of an epithelium
GO:9582; detection of abiotic stimulus
GO:72711; cellular response to hydroxyurea
GO:48478; replication fork protection
GO:76; DNA replication checkpoint signaling
GO:72719; cellular response to cisplatin
GO:1904976; cellular response to bleomycin
GO:43111; replication fork arrest
GO:122; negative regulation of transcription by RNA polymerase II
GO:30324; lung development
GO:48754; branching morphogenesis of an epithelial tube
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:35861; site of double-strand break
GO:31298; replication fork protection complex
GO:785; chromatin
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:42802; identical protein binding
Hide GO terms

Homologs of TIMELESS in Model Organisms

Danio rerio
wu:fd23d07
Drosophila melanogaster
timeout
Mus musculus
Timeless
Rattus norvegicus
Timeless
Saccharomyces cerevisiae
TOF1

In other databases

CellAge gene expression

External links

OMIM
603887
Ensembl
ENSG00000111602
Entrez Gene
8914
UniGene
118631
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TIMELESS
GeneCards
TIMELESS