The TLR2 gene and its putative association with human ageing

Cell Types

Embryonic kidney, Lung fibroblast

Cell Lines

HEK293T, IMR-90

Cancer Cell?

No

Method

Knockdown, Overexpression

Type of senescence

Oncogene-induced

Senescence Effect

Induces

Primary Reference

Hari et al. (2020) The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv 5(6)eaaw0254 (PubMed)

HGNC symbol

TLR2

Aliases

CD282; TIL4

Common name

toll like receptor 2

Entrez Id

7097

Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

Gene Ontology

Process:

GO:50896; response to stimulus
GO:45087; innate immune response
GO:6955; immune response
GO:1817; regulation of cytokine production
GO:2224; toll-like receptor signaling pathway
GO:2755; MyD88-dependent toll-like receptor signaling pathway
GO:2237; response to molecule of bacterial origin
GO:34134; toll-like receptor 2 signaling pathway
GO:50729; positive regulation of inflammatory response
GO:7165; signal transduction
GO:2376; immune system process
GO:6954; inflammatory response
GO:50830; defense response to Gram-positive bacterium
GO:10628; positive regulation of gene expression
GO:71346; cellular response to interferon-gamma
GO:45944; positive regulation of transcription by RNA polymerase II
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:7252; I-kappaB phosphorylation
GO:32722; positive regulation of chemokine production
GO:32728; positive regulation of interferon-beta production
GO:32735; positive regulation of interleukin-12 production
GO:32755; positive regulation of interleukin-6 production
GO:32757; positive regulation of interleukin-8 production
GO:32760; positive regulation of tumor necrosis factor production
GO:51770; positive regulation of nitric-oxide synthase biosynthetic process
GO:1901224; positive regulation of NIK/NF-kappaB signaling
GO:1903974; positive regulation of cellular response to macrophage colony-stimulating factor stimulus
GO:1904466; positive regulation of matrix metallopeptidase secretion
GO:6915; apoptotic process
GO:30177; positive regulation of Wnt signaling pathway
GO:34123; positive regulation of toll-like receptor signaling pathway
GO:51607; defense response to virus
GO:42495; detection of triacyl bacterial lipopeptide
GO:42496; detection of diacyl bacterial lipopeptide
GO:71223; cellular response to lipoteichoic acid
GO:71726; cellular response to diacyl bacterial lipopeptide
GO:71727; cellular response to triacyl bacterial lipopeptide
GO:1775; cell activation
GO:7612; learning
GO:14005; microglia development
GO:31663; lipopolysaccharide-mediated signaling pathway
GO:32741; positive regulation of interleukin-18 production
GO:38124; toll-like receptor TLR6:TLR2 signaling pathway
GO:50765; negative regulation of phagocytosis
GO:51964; negative regulation of synapse assembly
GO:71221; cellular response to bacterial lipopeptide
GO:1666; response to hypoxia
GO:1774; microglial cell activation
GO:6691; leukotriene metabolic process
GO:8285; negative regulation of cell population proliferation
GO:9636; response to toxic substance
GO:32289; central nervous system myelin formation
GO:32493; response to bacterial lipoprotein
GO:32496; response to lipopolysaccharide
GO:32570; response to progesterone
GO:32733; positive regulation of interleukin-10 production
GO:32868; response to insulin
GO:46209; nitric oxide metabolic process
GO:48714; positive regulation of oligodendrocyte differentiation
GO:70542; response to fatty acid

Cellular component:

GO:16021; integral component of membrane
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:45121; membrane raft
GO:9986; cell surface
GO:30670; phagocytic vesicle membrane
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
GO:43235; receptor complex
GO:31226; intrinsic component of plasma membrane
GO:30667; secretory granule membrane
GO:35354; Toll-like receptor 1-Toll-like receptor 2 protein complex
GO:35355; Toll-like receptor 2-Toll-like receptor 6 protein complex
GO:42995; cell projection
GO:44297; cell body

Function:

GO:4888; transmembrane signaling receptor activity
GO:5515; protein binding
GO:16787; hydrolase activity
GO:3953; NAD+ nucleosidase activity
GO:42802; identical protein binding
GO:50135; NAD(P)+ nucleosidase activity
GO:61809; NAD+ nucleotidase, cyclic ADP-ribose generating
GO:38023; signaling receptor activity
GO:1530; lipopolysaccharide binding
GO:1540; amyloid-beta binding
GO:1875; lipopolysaccharide immune receptor activity
GO:38187; pattern recognition receptor activity
GO:35325; Toll-like receptor binding
GO:42497; triacyl lipopeptide binding
GO:42834; peptidoglycan binding
GO:44877; protein-containing complex binding
GO:71723; lipopeptide binding

Hide GO terms

Danio rerio

tlr2

Drosophila melanogaster

Mus musculus

Rattus norvegicus

OMIM

Ensembl