Cell Senescence Entries for TLR3

Cell Types
Fibroblast, Keratinocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Liesenfeld et al. (2014) SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes. BMC Cancer 13(2)507 (PubMed)

TLR3 Gene Information

HGNC symbol
TLR3 
Aliases
CD283 
Common name
toll like receptor 3 
Entrez Id
7098
Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021].

TLR3 Ontologies

Gene Ontology
Process: GO:50896; response to stimulus
GO:45087; innate immune response
GO:6955; immune response
GO:51607; defense response to virus
GO:2224; toll-like receptor signaling pathway
GO:50729; positive regulation of inflammatory response
GO:1819; positive regulation of cytokine production
GO:2756; MyD88-independent toll-like receptor signaling pathway
GO:32722; positive regulation of chemokine production
GO:34138; toll-like receptor 3 signaling pathway
GO:43330; response to exogenous dsRNA
GO:7165; signal transduction
GO:2376; immune system process
GO:6954; inflammatory response
GO:10628; positive regulation of gene expression
GO:71260; cellular response to mechanical stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:32729; positive regulation of interferon-gamma production
GO:7252; I-kappaB phosphorylation
GO:32728; positive regulation of interferon-beta production
GO:32735; positive regulation of interleukin-12 production
GO:32755; positive regulation of interleukin-6 production
GO:32757; positive regulation of interleukin-8 production
GO:32760; positive regulation of tumor necrosis factor production
GO:45671; negative regulation of osteoclast differentiation
GO:1901224; positive regulation of NIK/NF-kappaB signaling
GO:7250; activation of NF-kappaB-inducing kinase activity
GO:97191; extrinsic apoptotic signaling pathway
GO:32727; positive regulation of interferon-alpha production
GO:165; MAPK cascade
GO:1774; microglial cell activation
GO:2730; regulation of dendritic cell cytokine production
GO:6952; defense response
GO:6972; hyperosmotic response
GO:7254; JNK cascade
GO:8584; male gonad development
GO:9597; detection of virus
GO:9615; response to virus
GO:32481; positive regulation of type I interferon production
GO:34123; positive regulation of toll-like receptor signaling pathway
GO:34346; positive regulation of type III interferon production
GO:35458; cellular response to interferon-beta
GO:42742; defense response to bacterium
GO:43065; positive regulation of apoptotic process
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:43331; response to dsRNA
GO:45766; positive regulation of angiogenesis
GO:46330; positive regulation of JNK cascade
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:71346; cellular response to interferon-gamma
GO:71360; cellular response to exogenous dsRNA
GO:71466; cellular response to xenobiotic stimulus
GO:97527; necroptotic signaling pathway
GO:98586; cellular response to virus
Cellular component: GO:16021; integral component of membrane
GO:5737; cytoplasm
GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5768; endosome
GO:5765; lysosomal membrane
GO:10008; endosome membrane
GO:5769; early endosome
GO:5615; extracellular space
GO:31012; extracellular matrix
GO:5887; integral component of plasma membrane
GO:139; Golgi membrane
GO:36020; endolysosome membrane
Function: GO:3725; double-stranded RNA binding
GO:4888; transmembrane signaling receptor activity
GO:5515; protein binding
GO:3723; RNA binding
GO:3953; NAD+ nucleosidase activity
GO:42802; identical protein binding
GO:38023; signaling receptor activity
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Homologs of TLR3 in Model Organisms

Danio rerio
tlr3
Mus musculus
Tlr3
Rattus norvegicus
Tlr3

In other databases

CellAge gene expression
  • This gene is present as TLR3

External links

OMIM
603029
Ensembl
ENSG00000164342
Entrez Gene
7098
UniGene
657724
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TLR3
GeneCards
TLR3