Cell Senescence Entries for TLR8

Cell Types
Breast cancer, Melanoma, Prostate cancer
Cell Lines
M628, MCF-7, PC-3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Ye et al. (2015) TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence. EMBO Mol Med 6(10)1294-311 (PubMed)

TLR8 Gene Information

HGNC symbol
TLR8 
Aliases
CD288; hTLR8 
Common name
toll like receptor 8 
Entrez Id
51311
Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008].

TLR8 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:6954; inflammatory response
GO:1817; regulation of cytokine production
GO:2755; MyD88-dependent toll-like receptor signaling pathway
GO:45089; positive regulation of innate immune response
GO:9615; response to virus
GO:32731; positive regulation of interleukin-1 beta production
GO:7249; I-kappaB kinase/NF-kappaB signaling
GO:71260; cellular response to mechanical stimulus
GO:2224; toll-like receptor signaling pathway
GO:32755; positive regulation of interleukin-6 production
GO:32729; positive regulation of interferon-gamma production
GO:32757; positive regulation of interleukin-8 production
GO:32727; positive regulation of interferon-alpha production
GO:32728; positive regulation of interferon-beta production
GO:16064; immunoglobulin mediated immune response
GO:34158; toll-like receptor 8 signaling pathway
GO:1932; regulation of protein phosphorylation
GO:32695; negative regulation of interleukin-12 production
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5768; endosome
GO:10008; endosome membrane
GO:5886; plasma membrane
GO:5789; endoplasmic reticulum membrane
GO:139; Golgi membrane
GO:36020; endolysosome membrane
GO:9897; external side of plasma membrane
Function: GO:3723; RNA binding
GO:3677; DNA binding
GO:4888; transmembrane signaling receptor activity
GO:3953; NAD+ nucleosidase activity
GO:42802; identical protein binding
GO:38023; signaling receptor activity
GO:38187; pattern recognition receptor activity
GO:3725; double-stranded RNA binding
GO:3727; single-stranded RNA binding
GO:5515; protein binding
Hide GO terms

Homologs of TLR8 in Model Organisms

Danio rerio
LOC100332583
Mus musculus
Tlr8
Rattus norvegicus
Tlr8

External links

OMIM
300366
Ensembl
ENSG00000101916
Entrez Gene
51311
UniGene
660543
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TLR8
GeneCards
TLR8